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Differential Roles of Rad18 and Chk2 in Genome Maintenance and Skin Carcinogenesis Following UV Exposure
Authors:Yuki Tanoue  Takeshi Toyoda  Jinghua Sun  Md. Kawsar Mustofa  Chie Tateishi  Shinya Endo  Noboru Motoyama  Kimi Araki  Di Wu  Yutaka Okuno  Tetsuya Tsukamoto  Motohiro Takeya  Hironobu Ihn  Cyrus Vaziri  Satoshi Tateishi
Affiliation:1. Department of Cell Maintenance, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan;2. Japan Society for the Promotion of Science (JSPS), Tokyo, Japan;3. Division of Pathology, National institute of Health Sciences Biological safety center, Tokyo, Japan;4. Departments of Hematology, Rheumatology, and Infectious Diseases, Kumamoto University Graduate School of Medicine, Kumamoto, Japan;5. Department of Human Nutrition, Sugiyama Jogakuen University School of Life Studies, Nagoya, Japan;6. Division of Developmental Genetics, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan;7. Department of Periodontology, Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, USA;8. Department of Diagnostic Pathology I, Fujita Health University School of Medicine, Toyoake, Japan;9. Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan;10. Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan;11. Department of Pathology, University of North Carolina, Chapel Hill, North Carolina, USA
Abstract:
Keywords:DSB  double-strand DNA break  ES  embryonic stem  MEF  murine embryonic skin fibroblast  PCNA  proliferating cell nuclear antigen  Polη  polymerase η  TLS  translesion synthesis  WT  wild-type  XP-V  xeroderma pigmentosum variant
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