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| Clinical observation on the changes in excitatory amino acids content in cerebrospinal fluid following acute spinal cord injury | |
| 引用本文： | 叶晓健,李家顺,李明,赵定麟,贾连顺. Clinical observation on the changes in excitatory amino acids content in cerebrospinal fluid following acute spinal cord injury[J]. 中国人民解放军军医大学学报, 1997, 0(4) |
| 作者姓名： | 叶晓健 李家顺 李明 赵定麟 贾连顺 |
| 作者单位： | Department of Orthopaedic Surgery，Changzheng Hospital，Second Military Medical University. Shang-hai，200003 |
| 摘 要： | Theprimarylossofneuronsresultingdirectlyfromtraumaatthetissuedamagesiteisfollowedbyasecondaryneuronalnecrosisextendingtoaconsiderabledistancefromthelesionepicenter.ThissecondaryInjurycausedmoreneuronallossthaninitialtraumaLIJ.Butthemechanismofsecondaryinjuryhasbeenelusive.Manyfactorsmaybeinvolved.Recently,theneurotoxicltyofexcitatoryamlnoacids(EAA)onneuronshasbeenrecognizedandmayplayanimportantroleinsecondaryinjury.Increasedextracellularlevelsofexcitatoryaminoacidswerefoundfollowingexperim… |
Clinical observation on the changes in excitatory amino acids content in cerebrospinal fluid following acute spinal cord injury |
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| Ye Xiaojian, Li Jiashun, Li Ming, Zhao Dinglin, Jia Lianshun. Clinical observation on the changes in excitatory amino acids content in cerebrospinal fluid following acute spinal cord injury[J]. Journal of Medical Colleges of PLA(China), 1997, 0(4) | |
| Authors: | Ye Xiaojian Li Jiashun Li Ming Zhao Dinglin Jia Lianshun |
| Abstract: | To elucidate the correlation between excitatory amino acids (EAA) and spinal cord injury, we investigat-ed the dynamic changes in excitatory amino acids, aspartate (Asp) and glutamate (Gin ) contents in cerebrospinalfluid (CSF) of 26 patients with acute spinal cord injury by amino acids autoanalyzer. The results showed that con-tent of glutanlate and aspartate was renlarkably elevated in 24 h after trauma and was related to the seventy of injury. The more severe the spinal cord injured, the more remarkable the content of Asp and Gin in CSF increased.The more pronounced the content of EAA in CSF increased, the worse the patient's prognosis was. Content of EAA in CSF after spinal cord injury may be an indicator to judge injury extent and prognosis. and provide further support for a potential pathophysiological role of EAA in spinal cord injury. |
| Keywords: | spinal cord injury cerebrospinal fluid excitatory amino acid |
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