奥扎格雷钠联合血栓通注射液治疗急性脑梗死疗效的系统评价

目的:系统评价奥扎格雷钠联合血栓通注射液治疗急性脑梗死(ACI)的疗效。方法:检索Cochrane图书馆临床对照试验资料库、PubMed、EMbase、中国生物医学文献数据库、中国期刊全文数据库、中文科技期刊全文数据库,纳入奥扎格雷钠联合血栓通注射液治疗ACI的随机对照试验(RCT),并手工检索其他的相关文献,对纳入研究进行方法学质量评价,并采用Rev Man 5.2.4统计软件进行Meta分析。结果:共纳入13项RCT,合计1 075例患者。Meta分析结果显示,奥扎格雷钠联合血栓通注射液可以显著提高患者的总有效率RR=1.24,95%CI(1.17,1.31),P<0.000]、痊愈率RR=1.96,95%CI(1.63,2.36),P<0.000],差异均有统计学意义。结论:奥扎格雷钠联合血栓通注射液治疗ACI疗效显著。由于纳入研究的质量不高,结论尚需设计严谨、大样本、高质量的RCT进一步证实。

A Systematic Review of Sodium Ozagrel Combined with Xueshuantong Injection in the Treatment of Acute Cerebral Infarction

OBJECTIVE： To evaluate the effectiveness and safety of sodium ozagrel combined with Xueshuantong injection for acute cerebral infarction （ACI）. METHODS： Retrieved from Cochrane Central Register of Controlled Trials, PubMed, EMbase, CBM, CNKI and VIP, randomized controlled trails （RCTS） about sodium ozagrel combined with Xueshuantong injection for ACI were included; while other relative researches were hand-searched, and methodology quality evaluation of included studies were conducted; Meta-analysis of those studies were carried out by Rev Man 5.2.4 statistical software. RESULTS： A total of 13 RCTs were included, involving 1 075 patients. Results of Meta-analysis showed sodium ozagrel combined with Xueshuantong injection could improve total response rate RR=1.24, 95%CI （1.17, 1.31）,P〈0.000] and cure rate RR=1.96,95%CI（1.63,2.36）,P〈 0.000] significantly; there was statistical significance. CONCLUSIONS： Sodium ozagrel combined with Xueshuantong injection improve total response rate and cure rate of ACI patients. It is effective in the treatment of ACI. However, because of the low methodological quality of the trials enrolled in the study, the well-designed, large-scale and high-quality RCTs are required to confirm the conclusion.