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食道癌患者CD4^+、CD25^+、Foxp3^+调节性T细胞的变化及意义
引用本文:胡正军,王胜军,李媛,成军,孙长贵,钱丽丽,刘永林,陈益民.食道癌患者CD4^+、CD25^+、Foxp3^+调节性T细胞的变化及意义[J].浙江中医药大学学报,2009,33(2):182-183.
作者姓名:胡正军  王胜军  李媛  成军  孙长贵  钱丽丽  刘永林  陈益民
作者单位:1. 浙江中医药大学附属第一医院,杭州,310006
2. 江苏大学医学技术学院
3. 浙江省义乌市疾病预防控制中心
4. 中国人民解放军117医院
摘    要:目的]初步探讨CD4^+CD25^+Foxp3^+调节性T细胞在食道癌患者外周血中的变化及临床意义。方法]59例食道癌患者,分为鳞癌组47例,腺癌组12例,另外30例健康志愿者为对照组,用流式细胞术分别检测外周血中CD4^+、CD25^+、Foxp3^+T细胞占CD4^+T细胞的比例。结果]食道癌初诊患者组CD4^+、CD25^+、Foxp3^+T细胞比例为(10.33±5.72)%,明显高于健康志愿者组(4.56±1.06)%(P〈0.01),而食道鳞癌组和食道腺癌组CD4^+、CD25^+、Foxp3^+T细胞比例没有明显差异。结论]CD4^+、CD25^+、Foxp3^+调节性T细胞在食道癌初诊患者外周血中比例增加,可能是食道癌免疫抑制的一个重要原因。

关 键 词:食道癌  CD4+CD25+调节性T细胞  叉状头/翅膀状螺旋转录因子

Changes of CD4~+,CD25~+,Foxp3~+ Regulatory T Cells in Patients with Esophageal Carcinoma and Its Possible Clinical Significance
Hu Zhengjun,Wang Shengjun,Li Yuan,et al..Changes of CD4~+,CD25~+,Foxp3~+ Regulatory T Cells in Patients with Esophageal Carcinoma and Its Possible Clinical Significance[J].Journal of Zhejiang University of Traditional Chinese Medicine,2009,33(2):182-183.
Authors:Hu Zhengjun  Wang Shengjun  Li Yuan  
Abstract:Objective] To investigate the changes of CD4+CD25+Foxp3+regulatory T cells (Tregs) in peripheral blood of patients with esophageal carcinoma and its possible clinical significance.Methods] The flow cytometry was used to evaluate the population of CD4+,CD25+,Foxp3+T cells in the peripheral blood of the patients with esophageal carcinoma before therapy and of the healthy donors.Results] The percentage of CD4+,CD25+,Foxp3+T cells of the esophageal carcinoma group before therapy was significantly higher than...
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