声诺维超声造影对兔肾射频消融灶的连续性评价

目的探讨声诺维（SonoVue）超声造影技术对正常肾脏射频消融灶术后效果的连续性评价作用。方法20只新西兰大白兔射频消融术后,采用SonoVue超声造影分别在术后1d、1周、1个月及3个月对消融灶进行观察评价,并将超声造影结果与大体标本消融灶结果对照分析。结果术后1d和1周,射频在兔肾产生的消融灶在切面上呈现楔形改变,传统超声不能显示消融灶的范围,超声造影准确地反映了消融灶的外观和大小,与大体标本消融灶实际的大小相差也仅1mm左右。在术后1个月和3个月时,消融灶在二维超声上呈高回声改变,超声造影可见肾内小的灌注缺损区,与大体测量的肾纤维结节大小相差也在1mm以内。结论SonoVue超声造影技术可以准确地反映正常肾脏射频消融后的发展及演变情况。

SonoVue-enhanced Ultrasonographic Evaluation of the Effect on Radiofrequency Ablation in Normal Rabbit Kidney

Objective To investigate the sequential evaluation of SonoVue-enhanced ultrasonography to the effect on radiofrequency ablaton in the normal kidney.Methods The lesions of 20 Newzealand rabbits produced by radiofrequency ablation were evaluated by conventional ultrasound and contrast-enhanced ultrasonography(CEUS)in the first day,first week,first month and third month.We compared CEUS with pathologic results.Results In the first day and first week after radiofrequency ablation,the ablaion lesions of the kidneys were wedge-shaped at the cross-section.Conventional ultrasound did not show the extent of the lesion,but CEUS could delineate the shape and size exactly.The difference was about 1 mm between CEUS and pathology.In the first month and third month after the ablation,the lesion turned to hyperechogenic on 2D-US and small perfusion defect on CEUS.The difference was <1 mm between CEUS and pathology.Conclusions SonoVue-enhanced ultrasonography may reveal the development and evolution of normal kidney after radiofrequency ablation.