Heterogeneity of class I and class II MHC sequences in Schistosoma mansoni |
| |
| Authors: | Ayumi Okada Atsuko Imase Hajime Matsuda Hiroshi Ohmae Hidekazu Hata Yukio Iwamura |
| |
| Affiliation: | (1) Center for Arts and Humanities, Ibaraki Prefectural University of Health Sciences, Ami 4669-2, Ami, Inashiki Ibaraki, 300-0394, Japan;(2) Department of Tropical Medicine and Parasitology, Dokkyo University School of Medicine, Mibu Tochigi, 321-0293, Japan;(3) Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba Ibaraki, 300-0394, Japan;(4) Institute of Experimental Animal Research, Graduate School of Medicine, Gunma University, Maebashi Gunma, 371-8511, Japan |
| |
| Abstract: | ![]()
We investigated the genetic variations in class I and class II major histocompatibility complex (MHC) genes of Schistosoma mansoni and the effects of host MHC genotypes. S. mansoni was maintained in combinations of two mouse strains with different MHC genotypes, and the MHC gene sequences of the cercariae were investigated. The detected class I MHC gene sequences were variable, with high similarity between the H-2Db murine host and the parasite. For other combinations, however, the parasite sequence was homologous to those of anthropoids. All class II MHC sequences detected in S. mansoni were homologous to those of anthropoids. Our results suggest that the genetic variation in the MHC sequences of S. mansoni is derived in part from the current host, indicating horizontal transfer of the sequences from mammal to parasite. |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
