雌、孕激素受体在甲状腺增生性疾病中的表达

目的:探讨雌激素受体(ER)和孕激素受体(PR)在甲状腺增生性疾病中的表达及临床意义,为临床治疗甲状腺增生性疾病寻求新的治疗靶点提供依据。方法:S-P染色法检测甲状腺癌、结节性甲状腺肿、甲状腺腺瘤及正常甲状腺组织中ER、PR的表达差异,以及ER、PR在甲状腺癌中的表达与患者肿瘤病理类型、淋巴结转移状态、年龄及性别的关系。结果:ER、PR在甲状腺癌组织中的表达与其在结节性甲状腺肿、甲状腺腺瘤及正常甲状腺组织中表达有显著性差异,而且与患者淋巴结转移状态、病理类型密切相关,与患者年龄、性别无关。结论:ER、PR受体状态与甲状腺癌高分化相关,可作为甲状腺癌患者预后的指标。本研究为临床寻找新的甲状腺增生性疾病治疗靶点提供了重要依据。

Expression of ER and PR in Thyroid Hyperplastic Diseases

Objective To investigate the expression and clinical significance of estrogen receptors(ER) and progesterone receptors(PR)in thyroid hyperplastic diseases and offer basis for seeking new target in thyroid hyperplastic diseases therapy.Methods S-P immunohistochemical technique was used to detect the different expression of ER and PR in tissues of thyroid cancer,nodular goiter,thyroid adenoma and normal thyroid tissues.The relationship of ER and PR in thyroid cancer with pathological type,the state of lymphatic metastasis,age and sex was analyzed.Results The positive rate of ER and PR in thyroid cancer was significantly higher than in nodular goiter,thyroid adenoma and normal thyroid tissues,and was closely related with pathological type and the state of lymphatic metastasis.However,positive expression of ER and PR was not related to age and sex.Conclusion The expression of ER and PR in thyroid cancer might be used as the markers to evaluate prognosis and provide new therapeutic targets in hyperplastic diseases therapy.