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Primary Immune Deficiencies Presenting in Adults: Seven Years of Experience from Iran |
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| Authors: | Davood Mansouri Parisa Adimi Mehdi Mirsaedi Nahal Mansouri Payam Tabarsi Majid Amiri Hamid R. Jamaati Masoud Motavasseli Noushin Baghaii Ali Cheraghvandi Reza Rouhi Navid A. Roozbahany Soheila Zahirifard Forouzan Mohammadi Mohammad R. Masjedi Ali A. Velayati Jean L. Casanova David P. Speert R. Kevin Elwood Robert Schellenberg Stuart E. Turvey |
| Affiliation: | (1) National Research Institute for Tuberculosis and Lung Diseases, Masih Daneshvary Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran;(2) Laboratory of Human Genetics of Infectious Diseases, University of Paris, Paris, France;(3) BC Children’s Hospital and BC Research Institute for Children’s and Women’s Health, Vancouver, BC, Canada;(4) Faculty of Medicine, University of British Columbia, BC Centre for Disease Control, Vancouver, BC, Canada;(5) Pulmonary Research Laboratory, University of British Columbia, Vancouver, BC, Canada;(6) Director Division of Infectious Diseases & Clinical Immunology, National Research Institute of Tuberculosis & Lung Diseases, Shahid Beheshti University of Medical Sciences, Niavaran (Bahonar) Avenue, Darabad, Tehran, Iran |
| Abstract: | Primary immunodeficiencies (PIDs) are not solely diseases of childhood. We describe the clinical presentation and outcome for 55 adult patients with previously unrecognized PIDs. This series provides unique data regarding PIDs presenting in adulthood, and serves as a timely reminder that physicians must consider the diagnosis of PIDs in their adult patients. Using the experience gained from these patients, we outline key “warning signs” suggestive of an underlying PID. Only through increased physician awareness will patients with PIDs receive timely diagnosis and optimal management. |
| Keywords: | Primary immunodeficiency adults Iran diagnostic delay |
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