| 正加速度对飞行员血浆降钙基因相关肽,内皮素水平和肾功能的… |
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| 引用本文： | 戴雨 纪桂英. 正加速度对飞行员血浆降钙基因相关肽,内皮素水平和肾功能的…[J]. 航天医学与医学工程, 1998, 11(1): 8-10 |
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| 作者姓名： | 戴雨 纪桂英 |
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| 摘 要： | 为观察正加速度（＋Ｇｚ）对飞行员血浆降钙素基因相关肽、内皮素及肾功能部分指标的影响。２０名飞行员不穿抗荷服，在离心机＋２．５Ｇｚ和＋３．０Ｇｚ分别作用１０ｓ，中间休息５ｍｉｎ。暴露前后２０ｍｉｎ两次抽肘静脉血。结果＋２．５Ｇｚ，＋３．０Ｇｚ能增长血浆中ＣＧＲＰ、内皮素。含量不会造成临床肾功能损害。
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| 关 键 词： | 正加速度 加速度应激 基因相关肽 飞行员 |
Effect of +Gz on plasma levels of calcitonin gene related peptide, endothelin and renal function in pilots. |
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| Y Dai,G Ji,D Dai,X Wang,L Xiao. Effect of +Gz on plasma levels of calcitonin gene related peptide, endothelin and renal function in pilots.[J]. Space Medicine & Medical Engineering, 1998, 11(1): 8-10 |
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| Authors: | Y Dai G Ji D Dai X Wang L Xiao |
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| Affiliation: | Department of Nuclear Medicine, General Hospital of Air Force, Beijing, China. |
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| Abstract: | The effect of positive acceleration on plasma levels of calcitonin gene related peptide (CGRP), and endothelin as well as renal function in pilots were observed in this study. 20 pilots were exposed to +2.5 Gz 10 s and +3.0 Gz 10 s with an interval of 5 min without anti-G suits. Samples of plasma and serum were taken 2Omin before and after exposure. Plasma levels of CGRP and endothelin after the exposure were significantly increased (P<0.01), but alkaline phosphatase(AKP), blood levels of beta 2-microglobulin(beta 2-MG), Ca2+ in serum showed no significant change (P>0.05) as compared with those before exposure. There was a correlation between CGRP and endothlin (r=0.772, P<0.01). It is concluded that positive acceleration(+2.5, +3.0Gz) could increase plasma levels of CGRP and endothlin but did not affect renal function. |
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