西酞普兰治疗脑卒中后抑郁对照研究

目的：比较西酞普兰与阿米替林治疗脑卒中后抑郁的疗效和安全性。方法：72例脑卒中后抑郁患者，随机分成两组，分别用西酞普兰和阿米替林治疗8周。采用汉密顿抑郁量表(HAMD)、Montgomerg-Asberg抑郁量表(MADS)和副反应量表(TESS)于治疗前和治疗后1、2、4、8周末分别评定疗效和不良反应。结果：西酞普兰组与阿米替林组间的HAMD、MADS评分差异均无显著性，西酞普兰组不良反应较阿米替林组少而轻。结论：西酞普兰治疗脑卒中后抑郁疗效好，安全性高，不良反应轻微。

A comparative study of citalopram and amitriptyline in post-stroke depression

Objective:To compare the efficacy and side effects of citalopram and amitriptyline on patients with post-stroke depression. Method:72 patients with post-stroke depression met the criteria of CCMD-3 for organic mental disorder were assigned randomly to citalopram group or amitriptyline group for eight weeks.The efficacy and side effects were assessed with HAMD,MADS and TESS before and 1,2,4,8 weeks after the treatment. Results:No differences were found in HAMD and MADS scores between two groups.Total scores of TESS were significantly lower in citalopram than in amitriptyline.However,citalopram had fewer side effects than amitriptyline. Conclusion:Citalopram is a safe and efficient drug in the treatment of post-stroke depression with good tolerance.