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| 微小卫星体不稳定性频繁表达于胃癌中 | |
| 引用本文： | 蔡建春,游枫红,张祥福,吴心愿,杨发端. 微小卫星体不稳定性频繁表达于胃癌中[J]. 中华消化杂志, 1998, 0(3) |
| 作者姓名： | 蔡建春 游枫红 张祥福 吴心愿 杨发端 |
| 作者单位： | 福建医科大学协和医院肿瘤科及临床肿瘤研究室，福州卫生检疫局，福建医科大学协和医院病理科 |
| 摘 要： | 目的对胃癌ＤＮＡ上５个重要座位进行分析，以探讨ＭＳＩ与胃癌生物学行为的关系。方法应用放射性ＰＣＲ为基础的技术对１０６例系列胃癌ＤＮＡ微小卫星体不稳定性（ＭＳＩ）进行测定。结果发现ＭＳＩ在一个或一个以上座位者占４１％（４４／１０６例）胃癌。分析ＭＳＩ与胃癌临床病理特点的关系发现。ＭＳＩ在膨胀性生长方式胃癌中的表达明显高于在浸润型生长方式胃癌中的表达（Ｐ＜０．００５），但ＭＳＩ的表达在不同的组织学类型，ＰＴＮＭ分期。年龄和性别差异无显著性（Ｐ＞０．０５）。结论上述发现揭示，ＭＳＩ可能在相当一部分胃癌，尤其是在传统上认为预后较好的膨胀性生长方式胃癌的发生发展过程中起着非常重要的作用。 |
| 关 键 词： | 微小卫星体不稳定性，胃肿瘤 |
Microsatellite instability occurs frequently in gastric cancer |
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| .Cai Jianchun.You Fenghong,Zhang Xiangfu,et al. Microsatellite instability occurs frequently in gastric cancer[J]. Chinese Journal of Digestion, 1998, 0(3) | |
| Authors: | .Cai Jianchun.You Fenghong Zhang Xiangfu et al |
| Affiliation: | .Cai Jianchun.You Fenghong,Zhang Xiangfu,et al Department of Oncology,and Institute ofClinical Cancer Research,Affiliated Union Hospital,Fujian Medical University,Fuzhou,350001 |
| Abstract: | Objective To study the association between MSI and biologicalbehavior at 5 loci in gastric cancer (GC).Method The presence of microsatelliteinstability(MSI)was evaluated in a series of 106 cases with GC using radioactivePCR-based technique.Results MSI at one or more loci was observed in 44(41%)of the 106 cases.The relationship of MSI with pathologic growth patterns wasassessed.The results showed that the frequency of MSI was significantly higher inexpanding type of GC compared to the infiltrative type of GC(P<0.005).NOsignificant association with histologic type.pTNM stage,age or sex was found in ourstudy(P>0.05).Conclusion These findings indicated that MSI might be animportant contributor to the pathogenesis of a significant number of GCs,especiallyin expanding type of GC which traditionally has a better prognosis. |
| Keywords: | Microsatellite instability Stomach neoplasm |
| 本文献已被 CNKI 等数据库收录！ | |