| 泛素-蛋白酶体抑制剂对大鼠肺成纤维细胞凋亡和增殖的影响 |
| |
| 引用本文： | 莫平征,叶燕青,韩晓. 泛素-蛋白酶体抑制剂对大鼠肺成纤维细胞凋亡和增殖的影响[J]. 武汉大学学报(医学版), 2011, 32(5): 581-584 |
| |
| 作者姓名： | 莫平征 叶燕青 韩晓 |
| |
| 作者单位： | 武汉大学中南医院呼吸内科 湖北武汉430071 |
| |
| 摘 要： | 目的:探讨泛素蛋白酶体抑制剂MG-132对大鼠肺成纤维细胞凋亡和增殖的影响,并初步探索其机制.方法:18只SD大鼠随机分成模型组(n=9)与对照组(n=9),模型组气管内一次性注入博莱霉素(5 mg/kg),对照组气管内注入等量无菌生理盐水,分别于7,28,45 d每组处死动物3只,提取成纤维细胞进行培养并用相同浓度的...
|
| 关 键 词： | 泛素蛋白酶体抑制剂 肺成纤维细胞 凋亡 增殖 |
Effect of Proteasome Inhibitor on Apoptosis and Proliferation of Pulmonary Fibroblasts |
| |
| MO Pingzheng,YE Yanqing,HAN Xiao. Effect of Proteasome Inhibitor on Apoptosis and Proliferation of Pulmonary Fibroblasts[J]. Medical Journal of Wuhan University, 2011, 32(5): 581-584 |
| |
| Authors: | MO Pingzheng YE Yanqing HAN Xiao |
| |
| Affiliation: | MO Pingzheng,YE Yanqing,HAN Xiao Dept.of Respiratory Medicine,Zhongnan Hospital of Wuhan University,Wuhan 430071,China |
| |
| Abstract: | Objective:To investigate the effect of proteasome inhibitor on apoptosis and proliferation of pulmonary fibroblasts in rats.Methods:Eighteen rats were randomly divided into model group(n=9) and control group(n=9).Model group received Bleomycin(5 mg/kg) by intratracheal instillation and the control group was treated with the same volume of saline.Three rats respectively in model group and in control group were sacrificed on the 7th,28th and 45th days respectively after the intratracheal instillation,and pulm... |
| |
| Keywords: | Proteasome Inhibitor Pulmonary Fibroblasts Apoptosis Proliferation |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
