| 持续氟西汀干预预防大鼠实验性肺动脉高压复发并改善生存率 |
| |
| 引用本文： | 王君钰,朱少平,赵金平,周雪峰,徐明. 持续氟西汀干预预防大鼠实验性肺动脉高压复发并改善生存率[J]. 武汉大学学报(医学版), 2011, 32(5): 573-577 |
| |
| 作者姓名： | 王君钰 朱少平 赵金平 周雪峰 徐明 |
| |
| 作者单位： | 1. 湖北省新华医院 湖北武汉 430015
2. 武汉大学中南医院胸心外科 湖北武汉430071 |
| |
| 基金项目： | 国家自然科学基金资助项目(编号:81101775); 中央部属高校专项科研基金资助项目(编号:111118) |
| |
| 摘 要： | 目的:观察氟西汀对野百合碱(MCT)所致的大鼠肺动脉高压(PAH)的近期和远期疗效及伴随的病理生理学变化.方法:实验分为氟西汀持续干预组(M+F组)、氟西汀短期干预组(M/F组)、MCT组及生理盐水组,共196只大鼠.其中前3组均先行MCT(60 mg/kg)皮下注射3周造模,M+F组为氟西汀(10mg/kg)干预9周...
|
| 关 键 词： | 5-羟色胺转运体 氟西汀 重构 复发 |
Continuous Fluoxetine Administration Prevents Recurrence of Pulmonary Arterial Hypertension and Prolongs Survival in Rats |
| |
| WANG Junyu,ZHU Shaoping,ZHAO Jinping,ZHOU Xuefeng,XU Ming. Continuous Fluoxetine Administration Prevents Recurrence of Pulmonary Arterial Hypertension and Prolongs Survival in Rats[J]. Medical Journal of Wuhan University, 2011, 32(5): 573-577 |
| |
| Authors: | WANG Junyu ZHU Shaoping ZHAO Jinping ZHOU Xuefeng XU Ming |
| |
| Affiliation: | WANG Junyu1,ZHU Shaoping2,ZHAO Jinping2,ZHOU Xuefeng2,XU Ming2 1Dept.of Oncology,Hubei Xinhua Hospital,Wuhan 430015,China 2Dept.of Thoracic and Cardiothoracic Surgery,Zhongnan Hospital of Wuhan University,Wuhan 430071,China |
| |
| Abstract: | Objective:To investigate the short-term and long-term therapeutic effects of fluoxetine on monocrotaline-induced pulmonary arterial hypertension(PAH) and associated pathophysiologic alterations in PAH models.Methods:A total of 196 rats were randomly distributed into three groups.Long-term fluoxetine treatment group(M+F,n=62) received a single subcutaneous injection of monocrotaline(MCT,60 mg/kg) for three weeks and then were treated with fluoxetine(10 mg/kg) once daily by gavage in the following nine weeks.... |
| |
| Keywords: | Serotonin Fluoxetine Remodeling Recurrence 5-HTT |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
