|
|||||
|
|
| 头孢菌素类抗生素脂质体的包封率测定与渗漏研究 | |
| 引用本文： | 罗云敬,刘海涛,李天剑,沈含熙. 头孢菌素类抗生素脂质体的包封率测定与渗漏研究[J]. 中国生化药物杂志, 1999, 0(1) |
| 作者姓名： | 罗云敬 刘海涛 李天剑 沈含熙 |
| 作者单位： | 南开大学化学系!天津300071 |
| 基金项目： | 国家自然科学基金!（批准号：29675009） |
| 摘 要： | 使用注射法和可控组装法制备了第三代头孢菌素类抗生素头孢曲松钠及头孢噻肟钠脂质体。平衡透析和微型柱－离心两种方法分离脂质体内外相中头孢菌素类抗生素，均具有良好的分离效果，且能得到较为相似的结果。建立的可控组装一紫外法可简便、准确地考察只具有紫外特性药物脂质体的效能。对它们的渗漏研究发现药物只能由脂质体内向外微量渗漏，而不被脂质体所摄取。 |
| 关 键 词： | 脂质体 头孢菌素 包封率测定 注射法 可控组装法 |
Determination of Encapsulation Efficiency and Release Test of Cephalosporins Liposome |
|
| Luo Yunjing,Liu Haitao,Li Tianjian,Shen Hanxi. Determination of Encapsulation Efficiency and Release Test of Cephalosporins Liposome[J]. Chinese Journal of Biochemical Pharmaceutics, 1999, 0(1) | |
| Authors: | Luo Yunjing Liu Haitao Li Tianjian Shen Hanxi |
| Abstract: | In this paper, injection and controlled assembling methods are used to prepare liposomes of the third generational cephalosporins-ceftriaxone and cefotaxime. Good and similar sePerated results can be obtained by using of dialysis and a minicolumn of sephadex G50. Established controlled assembling-UV method can simplely and accurately investigate efficiencies of medicines liposomes which only have ultra-visible adsorption. Cephalosporins could not be taken by liposome bacause they are water soluble, not liphatic soluble. |
| Keywords: | Liposome Cephalosporins Encapsulation efficiency Injection method Controlled assembling method |
| 本文献已被 CNKI 等数据库收录！ | |