|
|||||
|
|
Formation of Morphine Tolerance in Offspring of Morphine-Tolerant Animals: Neurochemical and Neuroimmune Correlates |
|
| Authors: | S V Litvinova V V Aristova V V Shul'govskii L A Basharova N N Terebilina L F Panchenko |
| Institution: | (1) Department of Higher Nervous Activity, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow;(2) Laboratory of Neuroimmunopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Science, Moscow;(3) Laboratory of Biochemistry, Institute of Narcology, Ministry of Health of Russian Federation, Moscow |
| Abstract: | We carried out a complex physiological, neurochemical, and neuroimmunologic study of the formation of tolerance to analgetic effect of morphine and analyzed enkephalinase A activity in different brain structures and serotonin antibodies in the serum. More early development of morphine tolerance and a sharp increase in serum antibody titer was found in the offspring of morphine-tolerant rats. This points to an imbalance in the neurotransmitter system and can serve as a diagnostic marker of endogenous opioid system pathology. |
| Keywords: | morphine tolerance offspring enkephalinase A serotonin antibodies |
| 本文献已被 PubMed SpringerLink 等数据库收录！ | |