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| NADPH氧化酶与男性勃起功能障碍 | |
| 引用本文： | 饶可,刘继红. NADPH氧化酶与男性勃起功能障碍[J]. 中华男科学杂志, 2009, 15(5): 455-458 |
| 作者姓名： | 饶可 刘继红 |
| 作者单位： | 华中科技大学同济医学院附属同济医院泌尿外科,湖北,武汉,430030 |
| 摘 要： | 勃起功能障碍是男性的常见病和多发病。目前认为氧化应激是引起阴茎勃起功能障碍的重要机制之一。NADPH氧化酶广泛存在于机体多个系统(包括阴茎组织),发挥重要的生理功能。在多种病理情况下,NADPH氧化酶可以在阴茎组织中催化合成大量活性氧,导致过度氧化应激,从而影响阴茎勃起功能。本文就NADPH氧化酶的组成、同源物、活性调节、生理功能、在勃起功能障碍中的作用以及在勃起功能障碍治疗中的应用作一综述。 |
| 关 键 词： | 勃起功能障碍 NADPH氧化酶 活性氧 |
NADPH Oxidase and Male Erectile Dysfunction |
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| RAO Ke,LIU Ji-hong. NADPH Oxidase and Male Erectile Dysfunction[J]. National journal of andrology, 2009, 15(5): 455-458 | |
| Authors: | RAO Ke LIU Ji-hong |
| Affiliation: | RAO Ke,LIU Ji-hongDepartment of Urology,Tongji Hospital Affiliated to Tongji Medical College,Huazhong University of Science , Technology,Wuhan,Hubei 430030,China |
| Abstract: | Erectile dysfunction(ED) is a common disease in men.Oxidative stress is indicated to be one of the important mechanisms of ED.NADPH oxidase expresses and plays significant psychological functions in many human organs,including the penis.In a variety of pathophysiological conditions,NADPH oxidase causes excessive oxidative stress through overproducing reactive oxygen species in the penis,and consequently induces erectile dysfunction.This paper reviews the composition,homologues,activation and physiological f... |
| Keywords: | erectile dysfunction NADPH oxidase reactive oxygen species |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |