| 大狼毒三萜类化学成分的研究 |
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| 引用本文： | 曹东,苏亚伦,杨峻山.大狼毒三萜类化学成分的研究[J].药学学报,1992,27(6):445-451. |
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| 作者姓名： | 曹东 苏亚伦 杨峻山 |
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| 作者单位： | 贵州省中医研究院，中国医学科学院药物研究所，中国医学科学院药物研究所 进修生 550002，北京 100050，北京 100050 |
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| 摘 要： | 自大戟科(Euphorbiaceae)植物大狼毒(Euphorbia nematocypha Hand—Mazz)根的乙醇提取物的苯溶解部分,经20%AgNO3硅胶层析,分离得到七个三萜类成分。根据光谱(IR,EIMS,1H—NMR和13C—NMR)和化学方法,确定其中一个化合物为新化合物,命名为大狼毒醇(nematocyphol,Ⅳa),其它化合物为已知物:印度荆芥醇乙酸酯(nepehinol acetate Ⅰ),日尔曼醇乙酸酯(germanicol acetate Ⅱ),大戟醇(euphol,Ⅲ),蒲公英醇(taraxasterol,Ⅴa),24-亚甲基环阿尔廷醇(24-methylenecycloartanol,Ⅴa)和印度荆芥醇(nepehinol,Ⅶa)。这些化合物均为首次从大狼毒中得到。
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| 关 键 词： | 大狼毒 三萜 大狼毒醇 |
| 收稿时间： | 1991-03-29 |
TRITERPENE CONSTITUENTS FROM EUPHORBIA NEMTOCYPHA HAND-MAZZ |
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| D Cao,YL Su,JS Yang.TRITERPENE CONSTITUENTS FROM EUPHORBIA NEMTOCYPHA HAND-MAZZ[J].Acta Pharmaceutica Sinica,1992,27(6):445-451. |
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| Authors: | D Cao YL Su JS Yang |
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| Institution: | Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing. |
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| Abstract: | Seven triterpenoids have been isolated from the roots of Euphorbia nematocypha Hand-Mazz. through chromatography on 20% AgNO3-silica gel. One of them was identified as a new compound named nematocyphol on the basis of spectral data (IR, EIMS, 1H-NMR and 13C-NMR). Its structure was deduced as IVa. Other compounds were identified as nepehinol acetate (I), germanicol acetate (II), euphol (III), tanaxastanol (Va), 24-methylenecycloartanol (VIa) and nepehinol (VIIa). These compounds were obtained for the first time from this plant. |
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| Keywords: | Euphorbia nematocypha Hand--Mazz Triterpenoids Nematocyphol |
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