Role of IGF-I signaling in muscle bone interactions |
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| Affiliation: | 1. VA Medical Center and University of California San Francisco, San Francisco, CA, USA;2. National and Kapodistrian University of Athens, Department of Physiology, Medical School, Goudi-Athens, Greece;3. Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, FL, USA;1. Department of Epidemiological Methods and Etiologic Research, Leibniz Institute for Prevention Research and Epidemiology — BIPS, Achterstr. 30, 28359 Bremen, Germany;2. Department of Biometry and Data Management, Leibniz Institute for Prevention Research and Epidemiology — BIPS, Achterstr. 30, 28359 Bremen, Germany;3. Research Centre in Epidemiology and Preventive Medicine — EPIMED, Department of Clinical and Experimental Medicine, University of Insubria, Via O Rossi 9, 21100 Varese, Italy;4. Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo Neuromed, Via dell''Elettronica, 86077 Pozzilli, Italy;5. Department of Chronic Diseases, Centre of Behavioural and Health Sciences, National Institute for Health Development, Hiiu St 42, 11619 Tallinn, Estonia;6. Department of Public Health and Community Medicine, University of Gothenburg, Medicinaregatan 16, 40530 Gothenburg, Sweden;7. Department of Paediatrics, Queen Silvia Children''s Hospital, University of Gothenburg, Rondvägen 10, SE 41686 Gothenburg, Sweden;8. Department of Pediatrics, University of Pécs, József A. u. 7, 7623 Pécs, Hungary;9. GENUD (Growth, Exercise, Nutrition and Development) Research Group, University School of Health Sciences, University of Zaragoza, C/Domingo Miral s/n, 50009 Zaragoza, Spain;10. Institute of Food Sciences, National Research Council, Via Roma 64, 83100 Avellino, Italy;11. Department of Public Health, Ghent University, UZ 2 Blok A De Pintelaan 185, 9000 Ghent, Belgium;12. Faculty of Mathematics and Computer Science, Bremen University, Bibliothekstr. 1, 28359 Bremen, Germany;1. Department of Molecular Cell Biology and Cancer Genomics Centre Netherlands, Leiden University Medical Center, The Netherlands;2. Institute for Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany;3. Berlin Brandenburg School of Regenerative Therapies (BSRT), Charité Universitätsmedizin, Berlin, Germany |
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| Abstract: | ![]()
Skeletal muscle and bone rely on a number of growth factors to undergo development, modulate growth, and maintain physiological strength. A major player in these actions is insulin-like growth factor I (IGF-I). However, because this growth factor can directly enhance muscle mass and bone density, it alters the state of the musculoskeletal system indirectly through mechanical crosstalk between these two organ systems. Thus, there are clearly synergistic actions of IGF-I that extend beyond the direct activity through its receptor. This review will cover the production and signaling of IGF-I as it pertains to muscle and bone, the chemical and mechanical influences that arise from IGF-I activity, and the potential for therapeutic strategies based on IGF-I.This article is part of a Special Issue entitled “Muscle Bone Interactions”. |
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