氯沙坦对STZ糖尿病大鼠肾脏超微结构的影响

目的 :观察血管紧张素受体拮抗剂氯沙坦对糖尿病大鼠肾脏超微结构的影响。方法 :雄性SD大鼠分为正常对照组 (NC)、糖尿病对照组 (DC)、糖尿病氯沙坦治疗组 (DL) ,治疗 12周 ,电镜观察各组肾脏超微结构的改变。结果 :DC组肾小球基底膜显著增厚 ,系膜和系膜细胞显著增生 ,DL组上述改变显著减轻。结论 :氯沙坦能够减轻或延缓糖尿病大鼠肾脏超微结构的改变 ,提示它能够对糖尿病肾脏产生一定的保护作用

Effects of losartan on renal ultrastructure in diabetic rats

Objective To observe the effects of losartan on renal ultrastructure in streptozotocin diabetic rats. Methods Male SD rats were randomly divided into 2 groups: normal control group (NC group) and diabetic group. Diabetic group was induced by streptozocin (65 mg·kg -1 ) abdominal injection. Four weeks later, diabetic rats were further divided into 2 groups: diabetic rats treated with losartan (DL group, 20mg·kg -1 ·d -1 , by gavage) and diabetic unteated control group (DC group). Renal ultrastructure of each group was observed before and after 12 weeks of treatment respectively. Results The ultrastructure alterations in DL group including mesangial expansion and thickening of glomerular basement membrane (GBM), were lighter than those in DC group. Conclusion Losartan can prevent renal pathological progress in diabetic rats. It is suggested that losartan may have some renal protective effects.