| 聚腺苷二磷酸核糖聚合酶的功能及其抑制剂潜在的临床应用 |
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| 引用本文： | 王慧源,孙宏斌. 聚腺苷二磷酸核糖聚合酶的功能及其抑制剂潜在的临床应用[J]. 中国临床药理学与治疗学, 2007, 12(7): 743-747 |
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| 作者姓名： | 王慧源 孙宏斌 |
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| 作者单位： | 中国药科大学新药研究中心,南京,210009,江苏 |
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| 摘 要： | 聚腺苷二磷酸核糖聚合酶（PARP）是人体重要的酶之一，参与染色质松弛、信号转录、DNA修复和细胞凋亡等生理过程。PABP过度激活则引起细胞坏死，从而介导多种病理过程。因此，抑制PARP可能会起到对某些疾病的治疗作用。本文综述了PARP的功能及PARP抑制剂的潜在临床应用。
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| 关 键 词： | 聚腺苷二磷酸核糖聚合酶 抑制剂 DNA损伤修复 细胞坏死 |
| 文章编号： | 1009-2501（2007）07-0743-05 |
| 修稿时间： | 2007-02-01 |
Physiological functions of poly(ADP-ribose)polymerase and potential clinical applications of its inhibitors |
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| WANG Hui-yuan,SUN Hong-bin. Physiological functions of poly(ADP-ribose)polymerase and potential clinical applications of its inhibitors[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(7): 743-747 |
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| Authors: | WANG Hui-yuan SUN Hong-bin |
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| Affiliation: | Center for Drug Discovery, China Pharmaceutical University, Nanjing 210009, Jiangsu, China |
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| Abstract: | Poly(ADP-ribose)polymerases(PARP) is one of the most important enzymes in human body. It plays an vital role in chromatin relaxation, signal transduction, DNA damage repair and apoptosis. Its over-activation induces necrosis and pathological processes. Therefore, inhibition of PARP may provide potential therapeutic approaches to treatment of a variety of diseases. This review presents an overview of PARP's functions and potential clinical applications of PARP inhibitors. |
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| Keywords: | poly(ADP-ribose)polymerase inhibitor DNA damage repair cell necrosis |
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