| 树脂吸附法分离纯化杜仲松脂醇二葡糖苷 |
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| 引用本文： | 彭密军,周春山,董朝清,雷启福,陈龙胜. 树脂吸附法分离纯化杜仲松脂醇二葡糖苷[J]. 中国生化药物杂志, 2004, 25(3): 147-150 |
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| 作者姓名： | 彭密军 周春山 董朝清 雷启福 陈龙胜 |
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| 作者单位： | 1. 中南大学,化学化工学院,湖南,长沙,410083;吉首大学,湖南,张家界,427000
2. 中南大学,化学化工学院,湖南,长沙,410083 |
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| 基金项目： | 湖南省科技厅攻关项目 ( 0 3NKY2 0 19)，湖南省教育厅青年重点项目 ( 0 2B0 2 8) |
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| 摘 要： | 目的筛选效果较好的树脂 ,对杜仲降压活性成分松脂醇二葡糖苷进行有效富集 ,提高产品质量。方法采用新型大孔吸附树脂对松脂醇二葡糖苷进行吸附及洗脱性能实验。同时采用高效液相色谱法进行分析检测。结果筛选出效果较好的S 8树脂 ,确定了最佳的工艺参数 ,使松脂醇二葡糖苷的含量由原材料中的 0 .0 85 %富集提高到 38.5 % ,得率达 85 .5 %。结论该法成本低 ,操作简单 ,树脂可重复使用 ,有较好的工业化前景
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| 关 键 词： | 松脂醇二葡糖苷 大孔吸附树脂 分离 纯化 |
| 文章编号： | 1005-1678(2004)03-0147-04 |
| 修稿时间： | 2003-06-27 |
Separation and purification of pinoresinol d-gluside in Eucommia ulmiodes by macroporous adsorption resin |
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| PENG Mi jun ,,ZHOU Chun shan ,DONG Chao qing ,LEI Qi fu ,CHEN Long sheng. Separation and purification of pinoresinol d-gluside in Eucommia ulmiodes by macroporous adsorption resin[J]. Chinese Journal of Biochemical Pharmaceutics, 2004, 25(3): 147-150 |
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| Authors: | PENG Mi jun ZHOU Chun shan DONG Chao qing LEI Qi fu CHEN Long sheng |
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| Affiliation: | PENG Mi jun 1,2,ZHOU Chun shan 1,DONG Chao qing 1,LEI Qi fu 1,CHEN Long sheng 1 |
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| Abstract: | PurposeTo choose suitable macroporous adsorption resins to enrich the active compound from Eucommia ,and pinoresinol d gluside (PDG), which show anti hypertensive activity.MethodsAdsorption and desorption characteristics of PDG were carried out on the resins. HPLC was used to determine the content of PDG.ResultsThe better resin S 8 was chosen, and the optimum parameters were obtained. The content of PDG was increased from 0.085% in the raw material to 38.5% in the product with a recovery of 85.5%.ConclusionThe resin adsorption is practicable method to isolate and purify PDG from Eucommia. |
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| Keywords: | pinoresinol d gluside macroporous adsorption resins separation purification |
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