STING受体在布鲁氏菌感染固有免疫中的作用机制研究进展

布鲁氏菌是兼性细胞内寄生的革兰氏阴性杆菌，可引起布鲁氏菌病，这是一种人兽共患的传染性疾病。固有免疫是保护宿主抵抗细胞内布鲁氏菌感染的首要防御措施，机体通过模式识别受体(PRRs)识别病原相关分子模式(PAMPs)(如来自病原体布鲁氏菌的非自我DNA)来发挥固有免疫。研究发现在布鲁氏菌感染中发挥作用的DNA受体包括TRL9、AIM2、STING,DNA受体感知布鲁氏菌DNA后通过一系列反应产生细胞因子引起固有免疫反应。本文就布鲁氏菌感染固有免疫通路中STING受体的识别、激活、信号级联以及其在宿主体内调节所发挥作用的最新进展进行综述。

Review of the innate immune mechanism of the STING receptor in Brucella infection

Brucella is a facultative intracellular parasitic Gram-negative bacterium that causes brucellosis, a highly contagious zoonotic disease. Innate immunity is the primary defense against intracellular Brucella infection. The body uses pattern recognition receptors to recognize pathogenic associated molecular patterns (e.g., non-self-DNA from the pathogen Brucella) to exert innate immunity. The DNA receptors with roles in Brucella infection include AIM2 and STING. After sensing Brucella DNA, DNA receptors generate cytokines through a series of reactions, thus evoking innate immune responses. In this review, the recognition, activation and signaling cascade of the STING receptor in the innate immune pathway responding to Brucella, as well as its regulation and roles in hosts, are reviewed.