ABO血型B_2和AB_2亚型血清学特征及人群分布研究

本研究旨在探讨ABO血型B2和AB2亚型的血清学特征、遗传背景和人群分布。采用经典的血型血清学试验技术检测先证者及其家庭成员血型,用自己研制的抗B1试剂血清对献血者进行B1/B2和AB1/AB2亚型分布调查。结果发现:先证者为AB2亚型、其子为B2亚型,先证者血清中含有抗B1抗体;2 318名B型献血者中发现3名为B2亚型,826名AB型献血者中发现2名为AB2亚型;先证者及3名献血者家系调查B2抗原均具有血型遗传学特征。结论:B2/AB2亚型是家族遗传,B2和AB2亚型分别占B型和AB型的0.129%、0.224%。

Serologic Characteristics and Population Distribtion of Subtypes B2 and AB2 of ABO Blood Group

This study was aimed to investigate the serologic characteristics,genetic background and population distribution of B2 and AB2 subtype in Chinese ABO blood group.The classic blood group serological technology was used to detect ABO blood group of the propositus and their family members,the anti-B1 serum prepared by ourself was used to investigate the distribution of B1/B2 and AB1/AB2 subtype of the blood donor.The results indicated that the antigen of propositus was AB2 subtype and that of his child was B2 subtype.The anti-B1 antibody was detected in blood serum of propositus;the antigen of 3 from 2318 blood donors with B blood group were found to be B2 subtype,the antigen of 2 from 826 blood donors with AB blood group were found to be AB2 subtype.The investigation on propositus and the 3 B2 blood donor families showed that B2 antigen displays genetic characteristics of blood group.It is concluded that B2/AB2 subtype is from family inheritance,while B2 subtype is amounted to 0.129% in B blood group,and AB2 subtype is amounted to 0.224% in AB blood group.