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| 一日1次溴新斯的明缓释片的制备及体内外释放行为研究 | |
| 引用本文： | 罗文,谭群友,熊华蓉,赵春景,张景勍. 一日1次溴新斯的明缓释片的制备及体内外释放行为研究[J]. 中国新药与临床杂志, 2011, 0(1) |
| 作者姓名： | 罗文 谭群友 熊华蓉 赵春景 张景勍 |
| 作者单位： | 重庆医科大学高校药物工程研究中心和生物化学与分子药理学重点实验室;中国人民解放军第三军医大学大坪医院野战外科研究所胸外科;重庆医科大学附属第二医院; |
| 基金项目： | 教育部博士点基金资助项目(20095503120008); 重庆市教育委员会资助项目(首批高等学校优秀人才资助,KJ090308) |
| 摘 要： | 目的以溴新斯的明为模型药物制备日服1次缇释片,并对缓释片释放特征进行初步考察。方法采用亲水凝胶骨架与薄膜包衣控释技术制备溴新斯的明缓释片,以药物释放行为为评价指标,对处方及工艺进行单因素考察结果溴新斯的明缇释片体外药物释放可维持24 h,药物释放曲线符合一级动力学方程In(100-Q)=-0.147 4 t+4.775 4,体内药动学研究表明缓释片t_(1/2)(5.1±1.8)h,较普通片t_(1/2)(3.5±1.1)h延长,具有较为明显的缓释效果。结论亲水凝胶骨架与薄膜包衣控释技术联合应用可以成功制备易溶性药物溴新斯的明的缓释制剂。 |
| 关 键 词： | 溴新斯的明 迟效制剂 释放度 |
Preparation and in vitro/in vivo release study of neostigmine bromide sustainedrelease tablets taken once daily |
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| LUO Wen,TAN Qun-you,XIONG Hua-rong,ZHAO Chun-jing,ZHANG Jing-qing. Preparation and in vitro/in vivo release study of neostigmine bromide sustainedrelease tablets taken once daily[J]. Chinese Journal of New Drugs and Clinical Remedies, 2011, 0(1) | |
| Authors: | LUO Wen TAN Qun-you XIONG Hua-rong ZHAO Chun-jing ZHANG Jing-qing |
| Affiliation: | LUO Wen~1,TAN Qun-you~2,XIONG Hua-rong~1,ZHAO Chun-jing~3,ZHANG Jing-qing~1 (1.Medicine Engineering Research Center in University,Chongqing Key Laboratory of Biochemical & Molecular Pharmacology,Chongqing Medical University,CHONGQING 400016,China,2.Department of Thoracic Surgery,Daping Hospital & Research Institute of Surgery,the Third Military Medical UniversitY of PLA,CHONGQING 400042,3.The Second Affiliated Hospital,CHONGQING 400010,China) |
| Abstract: | AIM To prepare once-daily sustained-release tablets of neostigmine bromide as a model drug and evaluate their release property.METHODS Neostigmine bromide sustained-release tablets were prepared with hydrophilic matrix and controlled release film coating technique.The formulation and preparation processes were screened and optimized by single factor tests according to drug release behavior.RESULTS The release of neostigmine bromide sustained-release tablets in vitro could last 24 h and fit the first kinetic... |
| Keywords: | neostigmine bromide delayed-action preparations release rate |
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