脂联素与代谢综合征

脂联素（APN）在＋276T/G、＋45T/G、164I/T、＋10211T/G、-11391G/A、-11377G/C等位点的基因多态性与代谢综合征（MS）及其相关性疾病有关。APN水平与三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）独立相关,血清APN水平降低是独立于体脂因素的胰岛素敏感性的因素之一,APN与2型糖尿病（T2DM）呈强负相关,APN水平与高血压发病呈独立负相关,低APN水平是MS的一个独立危险因素,血清APN水平降低是MS的特征性标志。APN水平与无粥样斑块的颈动脉内膜中层厚度呈负相关,是动脉粥样硬化早期的独立预测因子。APN与MS密切相关。

Adiponectin and metabolic syndrome

Adiponectin gene polymorphisms ＋276T/G、＋45T/G、164I/T、＋10211T/G、-11391G/A、-11377G/C are associated with metabolic syndrome,relating with other diseases,including obesity,dyslipidaemia,hypertension,Type 2 diabetes mellitus,atherosclerotic,cardiovascular diseases.The level of adiponectin is independently associated with triglyceride（TG）,total cholesterol （TC）,low-density lipoprotein（LDL） cholesterol and high-density lipoprotein（HDL） cholesterol.Low plasma concentration of adiponectin （hypoadiponectinaemia ）is one of the factors leading to insulin resistance which is independent of body fat.Adiponectin is strongly and inversely associated with type 2 diabetes.Hypoadiponectinaemia were found to be independently associated with a higher risk for the development of hypertension.Circulating adiponectin level is a strong risk marker for metabolic syndrome and hypoadiponectinaemia is a special sign of metabolic syndrome.Circulating adiponect level,which is inversely associated with carotid （without plaque） intima-media thickness（C-IMT）,independently predicts atherosclerosis in early stage.Adiponectin is associated closely with metabolic syndrome.