鱼的摄入与肾癌发病风险关系的Meta分析

目的应用meta分析的方法对各项研究进行系统分析以研究鱼的摄入与肾癌发病风险关系。方法在PubMed，Embase,
CNKI，CA中检索有关鱼及其产品的摄入与肾癌关系的病例对照研究以及队列研究的文献。通过meta分析方法研究鱼的摄入
与肾癌的关系。运用I2检验各项研究的异质性，并使用漏斗图检验发表偏倚。结果共纳入17篇文献，采用随机效应模型合并
分析后的结果未发现鱼的摄入与肾癌的发病风险相关（RR=0.90；95% CI，0.78~1.02）且异质性明显（P=0.003，I2=52.3%），针对
研究类型、研究地区以及发表时间进行亚组分析，同样没有明显的证据证明两者相关，但在性别亚组的分析中发现，男性增加鱼
的摄入可降低肾癌的发病率，而在女性中则没有关系。结论meta分析结果提示增加鱼的摄入未发现有预防肾癌发病的作用。

A meta-analysis of fish intake and the risk of renal cell cancer

Objective To explore the association of fish intake with the risk of renal cancer. Methods PubMed, Embase, CNKI
and CA databases were searched for case-control studies or cohort studies examining the relationship between fish or fish
products intake and renal cancer. Heterogeneity among the selected studies was assessed using I2 score, and the publication
bias was assessed using funnel plots. Results Seventeen articles were included in the analysis with a heterogeneity across the
studies (P=0.003, I2=52.3%). A random-effects model was used to generate the pooled risk ratio (RR) and 95% confidence
interval (CI), and no statistically significant association was found between the risk of renal cancer and fish intake (RR=0.90;
95% CI, 0.78-1.02). In subgroup analysis, no evidence was found that the study design, study region or publication date
influenced the results; but in the gender subgroup analysis, fish intake we found to decrease the risk of renal cancer in men but
not in women. Conclusion The results of meta-analysis do not support an association between fish intake and a lowered risk
of renal cancer.