蔗糖铁注射液联合红细胞生成素治疗维持性血液透析患者肾性贫血的疗效与安全性

目的 比较静脉应用蔗糖铁与口服多糖铁复合物对使用红细胞生成素.的维持性血液透析患者的肾性贫血的疗效与安全性.方法 采用同期随机对照研究,将接受维持性m液透析肾性贫血患者42例,随机分为静脉组和口服组各21例,分别给予蔗糖铁静脉推注和口服铁剂治疗,比较2组患者贫血治疗的效果及不良反应发生情况.结果 治疗后,血红蛋白(Hb)、红细胞压积(HCT)、血清铁蛋白(SF)、血清转铁蛋白饱和度(TSAT)的升高,静脉组较口服组差异有统计学意义(P<0.05);静脉组不良反应少于口服组(P<0.05).结论 在伴有缺铁的维持性血液透析患者肾性贫血的治疗中,蔗糖铁升高Hb的作用较口服铁剂更快,且不良反应发生率更低.

Efficacy and safety of intravenous iron sucrose combined with erythropoietin in the treatment of anemia in maintenance hemodialysis patients

Objective To investigate and compare the efficacy and safe-ty of intravenous iron sucrose with oral polysaccharide iron complex in erythropoietin treated in maintenance hemodialysis patients. Methods A randomized and controlled clinical study was used. Forty-two mainte-nance hemodialysis patients were derided into two groups, iv group and oral group, and were treated with the intravenous iron sucrose and oral polysaccharide iron complex separately. Results Hemoglobin (Hb) , hemotocrit (Hot), serum ferritin (SF) and transferrin saturation (TSAT) were significantly increased in both groups. However, the increment of these laboratory parameters was significantly higher in iv group than in oral group (P < 0. 05). There were less adverse effects in iv group than in oral group (P < 0.05). Conclusion Intravenous iron sucrose is effective and safety in treating anemic maintenance he-modialysis patients. It may induce Hb level to rise faster with less ad-verse effect.