| 冬虫夏草水提液抗心肌细胞缺氧再给氧损伤的实验研究 |
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| 引用本文： | 俞宙,何建新,王方方. 冬虫夏草水提液抗心肌细胞缺氧再给氧损伤的实验研究[J]. 南方医科大学学报, 1998, 0(2) |
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| 作者姓名： | 俞宙 何建新 王方方 |
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| 作者单位： | 广州军区总医院心内科!广州，510010 |
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| 基金项目： | 广东省科委重点攻关项目 |
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| 摘 要： | 采用荧光素染色法和ACAS570型粘附细胞仪观察冬虫夏草水提液对正常心肌细胞内Ca2+的作用及对缺氧再给氧时细胞内Ca2+的影响。结果显示：冬虫夏草水提液能降低正常心肌细胞内Ca2+的浓度，减轻缺氧再给氧时细胞内Ca2+超载现象，二者均呈良好的量效关系。提示冬虫夏草水提液可能有减轻缺氧再给氧损伤的作用。
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| 关 键 词： | 冬虫夏草 钙 缺氧再给氧损伤 |
The effect of Cordyceps sinensis on the injury of cultured neonatal rat myocardial cells due to anoxia-reoxygenation |
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| Yu Zhou, He Jianxin,Wang Fangfang. The effect of Cordyceps sinensis on the injury of cultured neonatal rat myocardial cells due to anoxia-reoxygenation[J]. Journal of Southern Medical University, 1998, 0(2) |
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| Authors: | Yu Zhou He Jianxin Wang Fangfang |
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| Abstract: | By using fluorescence staining method,the effect of Chinese herbal medicine Cordyceps sinensis on intracellular free calcium (Ca2+) level in cultured neonatal rat myocardial cells and in anoxia-reoxygenation myocardial cells were studied with adherent cell analysis and sorting cytometer 570 (ACAS 570). The results demonstrated that (1)The level of intracellular Ca2+ decreased immediately after the addition of Cordyceps sinensis; (2) Cordyceps sinensis significantly reduced the level of in tracellular Ca2+ due to anoxia-reoxygenation. All of these were dose-dependent. These showed that Cordyceps sinensis could a gainst calcium overload during anoxia-reoxygenation. |
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| Keywords: | Cordyceps sinensis calcium anoxia-reoxygenation injury |
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