肝脏局灶性结节性增生

目的：探讨肝脏局灶性结节性增生（FNH）的临床诊断特点及治疗选择。方法：回顾性分析28例经手术后病理证实为FNH患者的临床资料。结果：在28例患者中，20例（71.4%）无明显症状，24例（85.7%）肝功能正常，3例（10.7%）HBsAg阳性，甲胎蛋白及癌胚抗原检查均正常。超声检查20个（75.0%）病灶为低回声，超声造影3个（75%）病灶为快进慢出。多数病灶CT和MRI检查有特征性表现。治疗采用肝脏不规则切除术，24例定期随访3个月至6年。患者术后疗效确切,未见肿瘤复发，包括术后病理显示存在不典型增生的4个病灶。结论：FNH无特异性的临床表现；影像检查对其有较高的诊断价值；对有治疗指征者，手术切除是较好的选择。

Hepatic focal nodular hyperplasia

ObjectiveTo study the diagnosis and treatment of focal nodular hyperplasia(FNH). Methods : The clinical data of 28 patients with FNH treated by nonanatomic liver resection in our hospital were retrospectively analyzed. Results:Among the 28 patients, 20(71.4%) were asymptomatic, 24(85.7%) had normal liver function,and 3(11%) were HBsAg positive.The AFP and CEA levels were normal in all of the patients. On ultrasound, 20（75%）were hypoechoic lesions,and 3（75%）showed a typical hypervascular pattern in the arterial phase and slow wash out in the delay phase on contrast enhanced ultrasound. Multiphasic liver CT and MR imaging demonstrated characteristic features in most patients. All of the patients were treated by nonanatomic liver resection.Twenty-four patients were followed up for 3 months to 6 years.The postoperative outocme was satisfactory and had no recurrence in all the cases,including 4 lesions with dysplasisa on pathologic examination.Conclusions:FNH has nonspecific clinical manifestations. The imaging findings are of great value in diagnosis,and surgical resection is the optimal treatment for patient with distinct indications of surgery.