| Ⅰ型糖尿病HLA－DRB1等位基因分析 |
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| 引用本文： | 宋长兴,邱长春,朱席琳,胡秀玲,孟华,王甦民,刘东洋,白松梅,程杰,周文郁.Ⅰ型糖尿病HLA－DRB1等位基因分析[J].中国医学科学院学报,1995(5). |
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| 作者姓名： | 宋长兴 邱长春 朱席琳 胡秀玲 孟华 王甦民 刘东洋 白松梅 程杰 周文郁 |
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| 作者单位： | 北京市结核病胸部肿瘤研究所，中国医学科学院基础医学研究所 |
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| 基金项目： | 国家自然科学基金,北京市自然科学基金 |
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| 摘 要： | 应用ＰＣＲ／ＳＳＰ基因分型方法鉴定ＨＬＡ－ＤＲＢ１与北京地区胰岛素依赖型糖尿病的关系。证明ＩＤＤＭ的ＤＲ９频率较对照人群明显升高（３０．３％ｖｓ１７．９２％，ｘ２＝６．９７，Ｐ＜０．０１）；而ＤＲ３在ＩＤＤＭ中虽有升高，但无统计学意义（７．０％ｖｓ２．３６％ ｘ２＝３．１９，Ｐ＞０．０５）；糖尿病患者ＤＲ２频率明显降低（７．４％ｖｓ１９．８％，ｘ２＝９．６７，Ｐ＜０．０１）。上述结果表明ＤＲ９、ＤＲ３与ＩＤＤＭ易感呈正相关，而ＤＲ２与ＩＤＤＭ抗性相关。
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| 关 键 词： | Ⅰ型糖尿病，遗传易感性，序列特异性引物，基因分型 |
Analysis of HLA-DRB1 Alleles in Patients with IDDM |
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| Song Changxing, Qiu Changchun, Zhou Wenyu,Hu Xiuling,Meng Hua,et al.Analysis of HLA-DRB1 Alleles in Patients with IDDM[J].Acta Academiae Medicinae Sinicae,1995(5). |
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| Authors: | Song Changxing Qiu Changchun Zhou Wenyu Hu Xiuling Meng Hua |
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| Abstract: | HLA-DR association with IDDM in local population in Beijing was studied by PCR/SSPtyping. The frequency of HLA-DR9 was significantly higher in diabetic patients(30.3%45/148]vs l7.92%38/212],x2=6.97,P<8.3*10-3).DR3 was higher in diabetic patients in this study(7.0%10/148] vs 2. 36%5/212],x2=3. 19, P>0. 05) and DR2 was lower in patients with IDDM(7.4%11/148]vs 19.8%42/212],x2=9. 67, P<1.9* 10-3).These results suggest that DR9 and DR3 both were positively associated with IDDM, but DR2 was negatively associated with IDDM. |
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| Keywords: | type I diabetes genetic susceptibility sequence-specific primers generic typing |
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