| 促肾上腺皮质激素释放因子与肠易激综合征 |
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| 引用本文： | 常敏,方秀才. 促肾上腺皮质激素释放因子与肠易激综合征[J]. 基础医学与临床, 2011, 31(12) |
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| 作者姓名： | 常敏 方秀才 |
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| 作者单位： | 中国医学科学院北京协和医学院北京协和医院消化内科,北京,100730 |
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| 基金项目： | “十一五”国家科技支撑计划课题(2007BAI04B01) |
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| 摘 要： | 肠易激综合征(IBS)是一种个体特异性、多病因的异质性疾病,其发病和患者的精神状态、社会环境、生活应激等多种心理社会因素密切相关。促肾上腺皮质激素释放因子(CRF)是一种介导下丘脑-垂体-肾上腺(HPA)轴对应激反应的关键调节肽,参与脑-肠轴互动,通过影响胃肠道动力、内脏高敏感和肠道感染等参与IBS的发病。
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| 关 键 词： | 肠易激综合征 促肾上腺皮质激素释放因子 应激 |
Corticotropin-releasing factor and irritable bowel syndrome |
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| CHANG Min,FANG Xiu-cai. Corticotropin-releasing factor and irritable bowel syndrome[J]. Basic Medical Sciences and Clinics, 2011, 31(12) |
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| Authors: | CHANG Min FANG Xiu-cai |
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| Affiliation: | CHANG Min,FANG Xiu-cai(Dept.of Gastroenterology,PUMC Hospital,CAMS & PUMC,Beijing 100730,China) |
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| Abstract: | Irritable bowel syndrome(IBS) is a heterogeneous disease.The occurence of IBS is related to patient's mental status,social environment,life stress events and the other psychosocial factors.Corticotropin-releasing factor(CRF) is a key regulatory peptide in mediating the hypothalamus-pituitary-adrenal axis' response to stress and involves in the brain-gut axis interactions.CRF might be involved in IBS pathogenesis by altering gastrointestinal motility,visceral sensitivity,and the inflammation in the bowel. |
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| Keywords: | irritable bowel syndrome corticotropin-releasing factor stress |
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