| 10-23 脱氧核酶的生物催化功能研究进展 |
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| 引用本文： | 曾云,刘刚,凌保东. 10-23 脱氧核酶的生物催化功能研究进展[J]. 川北医学院学报, 2007, 22(6): 597-600 |
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| 作者姓名： | 曾云 刘刚 凌保东 |
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| 作者单位： | 川北医学院药物研究所,四川,南充,637007;川北医学院药物研究所,四川,南充,637007;川北医学院药物研究所,四川,南充,637007 |
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| 摘 要： | 10-23脱氧核酶是利用体外筛选技术得到的一种具有催化功能的单链DNA片段,具有高效的催化活性及特异的序列识别能力,能催化RNA特定部位的切割反应,从mRNA水平上抑制基因表达,具有潜在的治疗应用价值。
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| 关 键 词： | 10-23脱氧核酶 催化活性 基因治疗 |
| 文章编号： | 1005-3697（2007）06-0597-04 |
| 修稿时间： | 2007-10-15 |
Advances in Research of the Biocatalytic Activity of 10-23 deoxyribozyme |
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| ZENG Yun,LIU Gang,LING Bao-dong. Advances in Research of the Biocatalytic Activity of 10-23 deoxyribozyme[J]. Journal of North Sichuan Medical College, 2007, 22(6): 597-600 |
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| Authors: | ZENG Yun LIU Gang LING Bao-dong |
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| Affiliation: | Institute of Materia Medica, North Sichuan Medical College, Nanchong , 637007 |
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| Abstract: | 10-23 deoxyribozymes(10-23 DRz)are a set of single stranded DNA segments derived from a combinatorial library of sequences by selection technique in vitro.10-23 DRz have high biocatalytic activity and sequence specificity against the target mRNA and thus inhibit the gene expression at mRNA level.For this reason 10-23 DRz may be expected to be a new gene therapeutic tool. |
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| Keywords: | 10-23 deoxyribozyme Catalytic activity Gene therapy |
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