度洛西汀治疗持续性躯体形式疼痛障碍临床研究

目的观察度洛西汀治疗持续性躯体形式疼痛障碍临床疗效和药物不良反应。方法78例持续性躯体形式疼痛障碍患者按给药时间的不同，分为治疗组30例和对照组48例。治疗组给予度洛西汀；对照组给以氟西汀加小剂量阿米替林治疗。分别于治疗的2、4、6周评定对比2组的疼痛量表（MOSPM）、汉密尔顿抑郁量表（HAMD）和不良反应量表（TESS），观察疗效及其药物不良反应。结果2组患者在治疗的2、4、6周MOSPM疼痛缓解率和HAMD评分差异无统计学意义（P〉0．05）。治疗组于治疗的2、4周TESS评分明显低于对照组，差异有统计学意义（P〈0．01）。结论度洛西汀治疗持续性躯体形式疼痛障碍疗效相似于氟西汀加小剂量阿米替林，但药物不良反应明显降低。

Treatment of persistent somatoform pain disorder with Duloxetine

Objeqtive To observe the effect of duloxetine on persistent somatoform pain disorder.Methods Thirty patiens treated with duloxetine and 48 treated with fluoxetine plus Amitriptyline were enrolled.MOSPM,HAMD and TESS in two groups were observed during the 2nd.4th and 6th weeks.Results There was no significant difference on MOSPM and HAMD between two groups during 2nd.4th and 6th weeks.The score of TESS in duloxetine group during the 2nd and 4th week was obviously lower than that in control group(P＜0.01).Conclusion The curative effect of duloxetine for persistent somatoform pain disorder is similar to fluoxetine plus amitriptyline.but side effeeta of duloxetine is lower than fluoxetine plus amitriptyline.