大黄oe虫丸对四氧嘧啶型糖尿病小鼠降血糖作用研究

目的:研究大黄虫丸对四氧嘧啶所致糖尿病小鼠的降血糖作用。方法:腹腔注射四氧嘧啶90 mg.kg-1建立小鼠糖尿病动物模型,检测大黄虫丸对实验动物血糖、糖化血红蛋白及血脂的含量。造模前后称体重,解剖分离心、肝、脾、肺、肾、胸腺各脏器称重,计算脏器系数。结果:四氧嘧啶(90 mg.kg-1)ip小鼠,随着糖尿病模型的形成,小鼠的血糖升高,糖化血红蛋白的含量升高,体重下降及脾脏、胸腺重量减轻。大黄虫丸ig能降低四氧嘧啶糖尿病小鼠的血糖、糖化血红蛋白的水平,能升高高密度脂蛋白,能改善四氧嘧啶糖尿病小鼠的体重下降,增加脾脏及胸腺免疫器官重量。结论:大黄虫丸对糖尿病小鼠具有降血糖作用。

Studies on the Hypoglycemic Activity of Dahuang Zhechong Pill in Mice

Objective: To study the hypoglycemic effect of Dahuang Zhechong Pill on alloxan-induced diabetic mice. Methods: We made up animal models of diabetic mice by intraperitoneal injection of 90 mg·kg^-1 alloxan, the levels of glycated hemoglobin and lipids levels were measured. Mice were weighed before and after models made up. We anatomically separated the heart, liver, spleen, lung, kidney and thymus of the mice, weighed the organs and calculated the organ coefficient. Results: The level of blood glucose, glycated hemoglobin were increased, body weight and the weights of spleen, thymus were reduced after the models made up by introperitoneal injecting alloxan(90 mg·kg^-1)on mice. Dahuang Zhechong Pill could reduce the level of blood glucose, glycated hemoglobin, increase level of high-density lipoprotein and improved the weight loss of the alloxan-induced diabetic mice, and increase the weights of spleen and thymus of immune organs. Conclusion: Dahuang Zhechong Pill has hypoglycemic effect on diabetic mice.