| 铝对大鼠海马CA3区长时程增强维持的影响 |
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| 引用本文： | 李泉,肖鸿美,李艾,张自东. 铝对大鼠海马CA3区长时程增强维持的影响[J]. 华中科技大学学报(医学版), 2002, 31(5): 483-486 |
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| 作者姓名： | 李泉 肖鸿美 李艾 张自东 |
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| 作者单位： | 华中科技大学同济医学院基础医学院生理学系,武汉,430030 |
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| 基金项目： | 国家自然科学基金资助项目(No.39270591) |
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| 摘 要： | 应用细胞外电生理记录方法，探讨了铝对大鼠海马CA3区长时程增强（LTP）维持阶段的影响。结果表明：0.5mol/L以上浓度的铝能抑制海马CA3区LTP的维持过程，此抑制作用似与L-Arg-NO途径无关。而选择性钙通道阻断剂Diltiazem也抑制了LTP的维持过程，而且与铝有相互加强的作用，提示铝对维持阶段LTP的抑制作用至少部分地与细胞钙水平降低有关。
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| 关 键 词： | 海马 长时程增强 铝 钙阻断剂 大鼠 CA3区 |
Effect of Aluminium on the Maintenance of Long Term Potentiation in Hippocampal CA3 Area of Rats |
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| Abstract: | Using the technique of extracellular electrophysiological recording, the effect of aluminium on the maintenance of long term potentiation (LTP) in hippocampal CA3 area and its possible mechanism were studied. The results revealed that aluminium in appropriate concentration (over 0 5 mol/L) could block the maintenance of LTP. L Arg NO pathway might not be involved in this inhibitory effect of aluminium.The amplitude of PS might be attenuated significantly by aluminium or diltiazem and the effect of aluminium was additive with that of diltiazem. These data suggest that the inhibitory effect of aluminium at least is partly related to the intracellular free Ca 2+ level decrease. |
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| Keywords: | aluminium long term potentiation hippocampus Ca 2+ channel blocker |
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