Interstitial hyperthermia of malignant brain tumors by implant heating system: Clinical experience |
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| Authors: | Tastuya Kobayashi Yoshihisa Kida Takayuki Tanaka Kazuyoshi Hattori Masaaki Matsui Yoshifumi Amemiya |
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| Affiliation: | (1) Department of Neurosurgery, Nagoya University School of Medicine, Japan;(2) Department of Neurosurgery, Komaki City Hospital, Japan;(3) Department of Iron and Steel Engineering, Nagoya University School of Technology, Japan;(4) Department of Electrical Engineering, Chiba Institute of Technology, Japan;(5) Department of Neurosurgery, Komaki City Hospital, 1-20 Johbushi, 485 Komaki City, Japan |
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| Abstract: | ![]()
Summary An implant heating system using a ferromagnetic implant with low Curie temperature has been developed for treating human brain tumors. Safe and repeated hyperthermia was possible over periods averaging ten weeks in 23 out of 25 patients with malignant brain tumors without development of major side effects.Evaluation of the effects of this new treatment is still preliminary. Overall response rate was 34.8%. However, five of thirteen cases of malignant glioma and two of five cases of brain metastasis were responded well to interstitial hyperthermia given with or without irradiation. Pathological findings common to the treated tumors were circumscribed, ellipsoid shape of coagulation necrosis around the implant. Degeneration of tumor cells, hemorrhage, vascular stasis and thrombosis were found adjacent to the necrosis.In the future, a combination of interstitial hyperthermia with brachytherapy and chemotherapy may offer improved local control of brain tumor. |
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| Keywords: | interstitial hyperthermia implant heating system (IHS) malignant brain tumor Fe-Pt alloy Curie temperature coagulation necrosis |
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