丙戊酸钠静脉滴注治疗癫痫持续状态的疗效分析

目的探讨丙戊酸钠静脉滴注治疗癫痫持续状态（statusepilepticus，SE）的有效性及安全性。方法60例sE患者随机分为治疗组和对照组各30例，治疗组使用丙戊酸钠注射液，首剂以15mg／kg剂量缓慢静脉推注，推注时间5分钟。然后以1mg／（k·hr）的速度静滴。对照组使用地西泮注射液，首剂以10mg缓慢静脉推注，推注时间5分钟。随后以地西泮100mg溶于生理盐水500ml中，于12小时内缓慢静脉滴注。结果两组控制例数差异无统计学意义（P〈0．05）。治疗组复发率低于对照组，差异具有统计学意义（P〈0．05）。治疗组对呼吸、意识的影响小，差异具有统计学意义（P〈0．05）。结论静脉滴注丙戊酸钠治疗sE是一种有效的方法，不良反应少，值得临床推广应用。

The efficacy of intravenous administration of sodium valproate for epileptic state

Objective To explore the efficacy and safety of intravenous administration of sodium valproate for epileptic state （SE）. Methods 60 patients with SE were randomly divided into a study group and a control group, 30 for each group. The study group received a slow intravenous injection of sodium valproate at an initial dose of 15mg/kg for 5 minutes, and then an continuous infusion of 1 mg / （ kg·hr ） ; while the control group received a slow intravenous injection of diazepam at an initial dose of lOmg for 5 minutes, and then an intravenous drip with mixed solution of diazepam of 100 mg and 0.9% sodium chloride of 500 ml. Results There was no significant difference between the two groups in control cases （P〉0.05）. The recurrent rate was lower in the study group than in the control group, with a significant statistical difference （P〈0.05）. Sodium valproate had smaller effects on respiration and consciousness than diazepam, with a significant statistical difference （P〈0.05）. Conclusions Intravenous administration of sodium valproste is an effective method in the treatment of epileptic state. It has fewer adverse reactions and is worth popularizing clinically.