糖调节受损人群胰岛素早期分泌相与腰围的研究

目的探讨糖调节受损(IGR)人群胰岛素早期分泌相的变化及胰岛素早期分泌相与腰围的相关性。方法选取包钢糖尿病流行病学调查人群1 024例作为研究对象。所有研究对象均测量腰围、行口服葡萄糖耐量试验(OGTT)。根据OGTT结果划分糖耐量状态:糖耐量正常、空腹血糖受损、糖耐量低减、空腹血糖受损伴糖耐量低减、糖尿病(DM)。计算早期胰岛素分泌指数(△I30/△G30)。结果腹型肥胖组与非腹型肥胖组对比,IGR、DM的患病率明显增加。随着糖耐量恶化,△I30/△G30逐渐减少。胰岛素早期分泌相与腰围呈负相关,相关系数r=-0.716,p<0.01。结论胰岛素早期分泌相与腰围间有相关性。腰围可作为评估早期胰岛素分泌指数的指标。

Study on the relation between first-phase insulin secretion and waist circumference in impaired Glucose regulation individuals

Objective To investigate the change of the first-phase insulin secretion and the relation between first-phase insulin secretion and waist circumference in impaired glucose regulation individuals. Methods The investigation was performed in 1 024 workers of Baotou Iron ＆ Steel Company in prevalence of diabetes mellitus （DM）. The body waist circumference was examined in these subjects. Oral 75 g glucose tolerance test （OGTT） were tested, fasting plasma glucose （FPG）, fasting insulin （FINS）, 30 minute, 60 minute, 120 minute plasma glucose and insulin （PINS） after glucose intake were also tested. 1 024 subjects were divided into 5 groups based on the results of OGTT： normal glucose tolerance （NTG）, impaired fasting glucose （IFG）, impaired glucose tolerance （IGT）, impaired fasting glucose/impaired glucose tolerance （IFG/IGT） and DM. First-phase insulin secretion index （△I30/△G30） was calculated. Results Compared with the non-abdominal visceral obesity group, the subjects with abdominal visceral obesity group had significantly higher prevalence rate of impaired glucose regulation （IGR） and DM （p0.001-0.041）. With the deterioration of glucose tolerance （From NGT to IGR and DM）, △I30/△G30 were decreased. WC correlated with first-phase insulin secretion. Conclusion WC is correlate with first-phase insulin secretion. WC is a guideline of evaluating first-phase insulin secretion.