Antigen presentation by proliferating thymic macrophages to A (T,G)-A-L specific T cell line in an H-2 restricted manner |
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| Authors: | O Axelrod E Mozes R Gallily |
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| Affiliation: | 1. Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel;2. Lautenberg Center for General and Tumor Immunology, The Hebrew University - Hadassah Medical School, Jerusalem, Israel |
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| Abstract: | ![]()
Long-term cultures of murine homogeneous populations of Ia-bearing thymus-derived murine macrophages were tested for their ability to present antigen to a (T,G)-A-L specific IL-2-dependent continuous T cell line. Thymus-derived macrophages, with and without pretreatment for Ia induction, triggered efficiently antigen-specific T cell proliferation in an MHC restricted way. This experimental system, consisting of two normal proliferating homogeneous populations of macrophages and antigen specific T cells, provides an ideal tool for studying the mechanism of antigen presentation to T cells and for elucidation of the role of macrophages in T-B cell collaboration for antibody production. |
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| Keywords: | antigen-specific T cell line thymus-derived macrophages antigen presentation H-2 restriction T cell proliferation (T,G)-A-L IL-2 interleukin 2 MHC major histocompatibility complex Ag antigen Ac accessory cells APC antigen presenting cells RSA rabbit serum albumin CFA complete Freund's adjuvant ECM extracellular matrix LCM L-cell conditioned medium FCS fetal calf serum HS horse serum TDMØ thymus derived macrophages |
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