妊娠高血压综合征患者血清β绒毛膜促性腺激素及胎盘催乳素水平测定及其临

目的　探讨血清β绒毛膜促性腺激素 (β hCG)及胎盘催乳素 (HPL)的临床意义及其在妊娠高血压综合征 (妊高征 )发病中的作用。方法　用放射免疫法测定 142例正常妊娠妇女 (正常妊娠组 )及 43例妊高征妇女 (妊高征组 ,其中轻度 16例 ,中度 12例 ,重度 15例 )血清 β hCG及HPL水平。结果　 (1)轻、中、重度妊高征妇女血清 β hCG分别为 (2 5 33± 17 80 ) μg/L、(33 12± 4 91) μg/L、(42 19± 17 47) μg/L ;正常妊娠妇女为 (12 33± 7 92 ) μg/L ,妊高征组与正常妊娠组比较 ,差异有极显著性 (P <0 0 0 1)。β hCG水平与妊高征病情严重程度呈正相关(r=0 6 77,P <0 0 5 )。 (2 )轻、中、重度妊高征妇女血清HPL分别为 (14 73± 3 2 6 )mg/L、(11 44± 4 0 2 )mg/L、(12 73± 4 18)mg/L ;正常妊娠妇女为 (12 78± 4 6 7)mg/L。妊高征组与正常妊娠组比较 ,差异无显著性 (P >0 0 5 )。HPL水平与妊高征病情严重程度无相关 (r=- 0 30 0 ,P >0 0 5 )。结论　β hCG可反映妊高征时滋养细胞功能紊乱的程度及病情严重程度 ,可作为妊高征病情的监测指标之一。HPL水平的变化不能作为妊高征的检测指标。

Clinical significance of beta-hCG and human placental lactogen in serum of normal pregnancies and patients with pregnancy induced hypertension

OBJECTIVE: To examine the level of beta-hCG and Human Placental Lactogen (HPL) in maternal serum of normal pregnancies and patients with pregnancy induced hypertension (PIH) and to study the clinical significance and effects of them on the pathogenesis of the disease. METHODS: Serum levels of beta-hCG and HPL of 142 normal pregnant women and 43 patients with PIH (16 mild, 12 moderate and 15 severe) were determined by radioimmunossay. RESULTS: (1) Serum levels of beta-hCG in all PIH subgroups (25.33 +/- 17.80) micrograms/L in mild, (33.12 +/- 4.91) micrograms/L in moderate, (42.19 +/- 17.47) micrograms/L in severe] were significantly higher than the normal pregnant group (12.33 +/- 7.92) micrograms/L; P < 0.001]. There is positive correlation between levels of beta-hCG and degrees of PIH (r = 0.677, P < 0.05). (2) Serum levels of HPL in all PIH subgroups (14.73 +/- 3.26) mg/L in mild, (11.44 +/- 4.02) mg/L in moderate, (12.73 +/- 4.18) mg/L in severe] did not show significant difference when compared with that of normal pregnant group (12.78 +/- 4.67) mg/L; P > 0.05]. Furthermore, there was no correlation between levels of HPL and degrees of PIH (r = -0.300, P > 0.05). CONCLUSIONS: Serum beta-hCG could reflect the degree of functional imbalance of the placental trophoblasts on PIH and it may be used as a clinical detecting index of PIH. On the other hand, HPL is not such a useful factor.