局部晚期鼻咽癌放疗与化疗联合治疗进展

鼻咽癌(NPC)是常见的头颈部恶性肿瘤之一,放疗是NPC的主要治疗方法。化疗策略(诱导、同期、辅助)在放疗中的综合应用提高了局部晚期NPC的疗效。目前同期放化疗联合辅助或诱导化疗已被推荐为局部晚期NPC标准治疗方法。然而,标准治疗仍有许多不足之处,诱导及辅助化疗仍有许多争议,建立更加理想及个体化的局部晚期NPC放化疗方案仍是未来研究的方向。

Research progress on radiotherapy combined with chemotherapy for locally advanced nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is one of the common head and neck malignant tumors. Radiotherapy is the main treatment for NPC. The comprehensive application of chemotherapy strategies (induction, concurrent and adjuvant) in radiotherapy has improved the efficacy in the treatment of locally advanced NPC. Based on current evidence, concurrent chemoradiotherapy combined with adjuvant or induction chemotherapy has been recommended as the standard treatment for locally advanced NPC. However, there are still many deficiencies in the standard treatment, and the application of induction and adjuvant chemotherapy remains controversial. Establishing a more ideal and individualized chemoradiotherapy for locally advanced NPC is still the research direction in the future.