组胺H3受体在精神分裂症阴性症状和认知功能中的研究进展

 精神分裂症是一种严重的神经精神障碍，阴性症状和认知功能是精神分裂症的核心症状，其发病机制与各种神经递质系统的失调有关。组胺H3受体及拮抗剂在中枢神经系统中发挥独特且关键的作用，可以作为重要的药物干预靶点。目前，H3受体拮抗剂/反向激动剂对改善精神疾病的阴性症状和认知功能的结论不一致。因此，本文对组胺能H3受体及其拮抗剂在精神分裂症阴性症状和认知功能中的作用作一阐述，并对H3受体及其拮抗剂在精神分裂症阴性症状和认知功能治疗中的潜在用途进行展望。

The progress on the effect of histaminergic H3 receptor on negative symptoms and cognitive function of schizophrenia

Schizophrenia is a severe neuropsychiatric disorder with the core symptoms of negative symptoms and cognitive functioning, the pathogenesis of which is associated with dysregulation of various neurotransmitter systems. Histamine H3 receptors and antagonists play a unique and critical role in the central nervous system and can serve as potent targets for pharmacological intervention. Currently, there are inconsistent findings on the effects of H3 receptor antagonists/inverse agonists on improving negative symptoms and cognitive function in schizophrenia. Therefore, this article provides an account of the role of histaminergic H3 receptors and their antagonists in negative symptoms and cognitive function in schizophrenia. An outlook on the potential use of H3 receptors and their antagonists in the treatment of negative symptoms and cognitive function in schizophrenia.