| 石松生物碱化学成分的研究 |
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| 引用本文： | 刘慧杰,汪冶. 石松生物碱化学成分的研究[J]. 中国中药杂志, 2012, 37(4): 475-477 |
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| 作者姓名： | 刘慧杰 汪冶 |
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| 作者单位： | 贵州省中国科学院天然产物化学重点实验室,贵州贵阳,550002 |
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| 基金项目： | 国家自然科学基金项目(30860344) |
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| 摘 要： | 目的:研究石松Lycopodium japonicum生物碱化学成分。方法:采用硅胶柱色谱,RP-C18反相柱色谱,SephadexLH-20柱色谱,Waters半制备液相色谱等方法分离纯化,根据理化性质和波谱数据鉴定化合物的结构。结果:从石松中分离并鉴定了9个生物碱化学成分,分别为lycodoline(1),lucidioline(2),α-obscurine(3),lycopodine(4),lycoposerramine-L(5),lyco-poserramine-M(6),11α-O-acetyl-lycopodine(7),des-N-methyl-α-obscurine(8),clavolonine(9),其中化合物4～9为首次报道从石松中分离得到。
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| 关 键 词： | 石松属 石松 生物碱 化学成分 |
| 收稿时间： | 2011-06-17 |
Study on chemical constituents of Lycopodium alkaloids |
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| LIU Huijie and WANG Ye. Study on chemical constituents of Lycopodium alkaloids[J]. China Journal of Chinese Materia Medica, 2012, 37(4): 475-477 |
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| Authors: | LIU Huijie and WANG Ye |
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| Affiliation: | The Key Laboratory for Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, China;The Key Laboratory for Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, China |
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| Abstract: | Objective:To study the alkaloid chemical constituents of Lycopodium japonicum.Method:Compounds were isolated and purified by such methods as silica gel column chromatography,RP-C18 reversed phase column chromatography,Sephadex LH-20 column chromatography and Waters semi-preparative liquid chromatogram,and their structures were identified based on physicochemical property and spectrum data.Result:Nine known alkaloid chemical constituents were isolated and identified,they were lycodoline(1),lucidioline(2),α-obscurine(3),lycopodine(4),lycoposerramine-L(5),lycoposerramine-M(6),11α-O-acetyl-lycopodine(7),des-N-methyl-a-obscurine(8),clavolonine(9).Conclusion:Compounds 4-9 were obtained from L.japonicum for the first time. |
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| Keywords: | Lycopodium genus Lycopodium japonicum alkaloid chemical constituents |
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