| 微波辐射法合成5-H/氯（苯并三氮唑甲基）四氮唑类化合物 |
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| 引用本文： | 蚩会丽,许秀枝,王艰,李柱来.微波辐射法合成5-H/氯（苯并三氮唑甲基）四氮唑类化合物[J].福建医科大学学报,2011,45(5):348-350. |
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| 作者姓名： | 蚩会丽 许秀枝 王艰 李柱来 |
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| 作者单位： | 福建医科大学药学院,福州,350004 |
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| 基金项目： | 福建医科大学教授基金(js10005); 福建省教育厅科技项目(JA11115) |
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| 摘 要： | 目的用微波辐射催化法合成5-H/氯（苯并三氮唑甲基）四氮唑类化合物。方法在微波辐射条件下,以三乙胺盐酸盐为催化剂,2-（5′-H/氯苯并三氮唑）乙腈系列化合物和叠氮化钠在甲苯溶剂中回流0.5h得到目标化合物。结果合成得到5个相应的四氮唑类化合物,其中4个新化合物通过熔点、IR和1 H-NMR确认结构,产率在70%～90%。结论使用微波辐射法合成目标产物,与传统加热方法（回流36h,产率64%）相比较,具有时间短、产率高的优点。
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| 关 键 词： | 微波 叠氮化钠 三乙胺盐酸盐 工艺学 制药 催化作用 |
Synthesis of 5-H/Cl(Benzotriazol-ylmethyl)-Terazole by Microwave Irradiation |
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| CHI Huili,XU Xiuzhi,WANG Jian,LI Zhulai.Synthesis of 5-H/Cl(Benzotriazol-ylmethyl)-Terazole by Microwave Irradiation[J].Journal of Fujian Medical University,2011,45(5):348-350. |
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| Authors: | CHI Huili XU Xiuzhi WANG Jian LI Zhulai |
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| Institution: | CHI Huili,XU Xiuzhi,WANG Jian,LI Zhulai Department of Pharmacy,Fujian Medical University,Fuzhou 350004,China |
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| Abstract: | Objective 5-H/Cl(Benzotriazol-ylmethyl)terazoles were synthesized by microwave irradiation.Methods A mixture of cyanomethyl-benzotriazol,sodium azide and triethylamine hydrochloride was refluxed in toluene for half an hour by microwave irradiation.Result Five target compounds were synthesized and four of them were new compounds with yields of 70%~90%.They were further characterized by melting point measurement,IR and 1H-NMR analysis.Conclusion Synthesis of target terazole compounds by microwave irradiation ... |
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| Keywords: | microwaves Sodium Azide triethylamine hydrochloride technology pharmaceutical catalysis |
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