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| IL-6基因启动子多态性与乳腺癌风险的关联性 | |
| 作者姓名： | He KL Li YP Lv YG Zhang DJ Wang H |
| 作者单位： | 1. 西北工业大学医院普外科,陕西西安,710072 2. 第四军医大学西京医院血管内分泌外科,陕西西安,710032 3. 西安交通大学第一附属医院普外科,陕西西安,710061 |
| 基金项目： | 西京医院学科助推计划项目(XJZT10M06) |
| 摘 要： | 目的:探讨白介素-6(IL-6)基因启动子区-597G/A(rs1800797)、-572C/G(rs1800796)和-174G/C(rs1800795)三个单核苷酸多态性位点(SNP)和乳腺癌易感性的关联性。方法:按照诊断标准,入组女性乳腺癌患者176例及年龄、体重指数等相匹配的健康女性200例。提取外周静脉血DNA,采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术检测IL-6基因启动子区-597G/A、-572C/G和-174 G/C三个SNPs位点的基因型。利用SPSS11.5软件进行χ2检验,比较乳腺癌患者各位点基因型、等位基因频率与健康女性之间的差异,分析各位点多态性与乳腺癌发病风险的关联性。结果:IL-6基因-572C/G位点的基因型及等位基因频率分布在乳腺癌组与健康组之间存在显著性差异(P<0.05),乳腺癌组-572C/G位点的等位基因G频率显著高于健康组(χ2=15.438,P<0.0001,OR=2.017,95%CI=1.417～2.870)。结论:IL-6基因-572C/G位点多态性与乳腺癌易感性相关联,携带有-572G/C多态性位点G等位基因的女性罹患乳腺癌的风险要高于非携带女性。 |
| 关 键 词： | 乳腺癌 IL-6 单核苷酸多态性 聚合酶链反应 |
Association between polymorphisms of interleukin-6 gene promoter and breast cancer |
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| He KL,Li YP,Lv YG,Zhang DJ,Wang H.Association between polymorphisms of interleukin-6 gene promoter and breast cancer[J].Journal of Cellular and Molecular Immunology,2011,27(11):1220-1222. | |
| Authors: | He Kai-liang Li Yong-ping Lv Yong-gang Zhang Dan-jie Wang Hui |
| Institution: | HE Kai-liang,LI Yong-ping,L(U) Yong-gang,ZHANG Dan-jie,WANG Hui |
| Abstract: | AIM: To study possible association between three single nucleotide polymorphisms(-597G/A,-572C/G and-174G/C) of interleukin-6(IL-6) gene promoter and breast cancer.METHODS: Genomic DNA was isolated from the venous blood leukocytes from 176 unrelated patients with breast cancer and 200 healthy unrelated females(control group).Polymorphisms of-597G/A,-572C/G and-174G/C,were genotyped by PCR-restriction fragment length polymorphisms(PCR-RFLP).SPSS 11.5 software was employed for statistical analysis and the ass... |
| Keywords: | breast cancer interleukin-6 single nucleotide polymorphism PCR |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ | |