趋化因子受体CXCR4/CXCL12在结肠癌中的表达及其与结肠癌肝转移的关系研究

目的检测趋化因子受体CXCR4/CXCL12信号转导通路在结肠癌组织、远离癌正常黏膜中的表达情况,分析CXCR4/CXCL12在结肠癌肝结转移中的作用。方法免疫组织化学染色方法检测84例直肠癌标本中CXCR4和CXCL12的表达,并对其与结肠癌肝转移的关系进行分析。结果 CXCR4在结肠癌组织中的阳性表达率为53.6%,其中伴肝转移组和无伴肝转移组阳性表达率分别为58.7%、22.1%,两者差异有统计学意义(P<0.05),CXCL12在结肠癌组织中的阳性表达率为56%,其中伴肝转移组和无伴肝转移组阳性表达率分别为62.3%、25.8%,两者差异有统计学意义(P<0.05)。结论 CXCR4、CXCL12在结肠癌中高表达,CXCR4/CXCL12信号转导通路可能在结肠癌肝转移过程中起重要作用。

Research for expression of chemotaxis factor receptor CXCR4/CXCL12 in the colon cancer and its relationship between hepatic metastasis of colonic carcinoma

Objective To test the expression of chemotaxis factor receptor CXCR4/CXCL12 signal transduction pathways in colon cancer organizations and far from normal mucosa carcinoma.Analyzing the function of CXCR4/CXCL12 for hepatic metastasis of colonic carcinoma.Methods Detecting the expression of CXCR4/CXCL12 of 84 patients’ specimens with colorectal cancer by immunochemistry staining,anlyzed the relationship between CXCR4/CXCL12 and hepatic metastasis of colonic carcinoma.Results The positive rate of CXCR4 in colon cancer tissue were 53.6%,the positive rate of liver metastases were 58.7% and the positive rate of no liver metastases were 22.1%,there was significant difference(P < 0.05),the positive rate of CXCL12 in colon cancer organizations were 56%,the positive rate of liver metastases were 62.3% and the positive rate of no liver metastases were 25.8%.There was significant difference(P < 0.05).Conclusion There was a high expression of CXCR4 and CXCL12 in colon cancer,the function of CXCR4/CXCL12 signal transduction pathways for hepatic metastasis of colonic carcinoma was important.