| 白藜芦醇对大鼠脑创伤后伤区脑组织神经细胞凋亡的影响 |
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| 引用本文： | 周杰,雷鹏,章翔,蒋晓帆,荔志云,武弋,黄艳萍. 白藜芦醇对大鼠脑创伤后伤区脑组织神经细胞凋亡的影响[J]. 创伤外科杂志, 2008, 10(1): 20-24 |
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| 作者姓名： | 周杰 雷鹏 章翔 蒋晓帆 荔志云 武弋 黄艳萍 |
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| 作者单位： | 1. 兰州军区兰州总医院神经外科,甘肃,兰州,730050
2. 第四军医大学西京医院神经外科,陕西,西安,710032 |
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| 摘 要： | 目的 探讨白藜芦醇(resveratrol,Res)对大鼠脑创伤后神经细胞凋亡的影响及可能的作用机制.方法 采用改良的Feeney自由落体脑损伤模型,对颅脑损伤大鼠用Res(50mg/kg,ip)治疗,应用原位末端标记法(TUNEL)及免疫组织化学方法检测受损脑组织治疗前后TUNEL阳性细胞数、Bcl-2及Bax的表达变化.结果 治疗组大鼠脑组织TUNEL及Bax表达阳性细胞数低于创伤组及对照组(P＜0.05),Bcl-2表达伤后持续升高,治疗组高于对照组和创伤组(P＜0.05),创伤组和对照组差异不明显(P＞0.05).结论 白藜芦醇具有抗凋亡作用,可能是通过抑制促凋亡因素,促进抑凋亡因素表达来减少颅脑损伤后神经细胞的凋亡,发挥脑保护作用,其详细机制有待进一步研究.
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| 关 键 词： | 颅脑损伤 白藜芦醇 末端标记法 白藜芦醇 大鼠脑组织 创伤后 神经细胞凋亡 影响 head injury rats tissue brain impaired apoptosis neural resveratrol 研究 脑保护作用 颅脑损伤后 因素 促凋亡 抗凋亡作用 差异 |
| 文章编号： | 1009-4237(2008)01-0020-05 |
| 修稿时间： | 2007-02-07 |
Effect of resveratrol on the neural apoptosis of impaired brain tissue in rats with head injury |
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| ZHOU Jie,LEI Peng,ZHANG Xiang,et al.. Effect of resveratrol on the neural apoptosis of impaired brain tissue in rats with head injury[J]. Journal of Traumatic Surgery, 2008, 10(1): 20-24 |
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| Authors: | ZHOU Jie LEI Peng ZHANG Xiang et al. |
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| Affiliation: | ZHOU Jie,LEI Peng,ZHANG Xiang,et al.(Department of Neurosurgery,Lanzhou General Hospital,Lanzhou Comm,,Lanzhou 730050,China) |
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| Abstract: | Objective To investigate the effects and possible mechanisms of resveratrol on neural apoptosis of impaired brain tissue in rats with head injury.Methods The craniocerebral injury model was created by Feeney's methods,local brain injury rats were treated with resveratrol(50mg/kg,ip).Immunohistochemisty was used to detect the apoptosis index of TUNEL and expression of Bcl-2 and Bax in the impaired brain tissue.Results The apoptosis index of TUNEL and percentage of Bax positive cells in the treatment group we... |
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| Keywords: | brain injury resveratrol TUNEL |
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