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| 姜黄素对大鼠血瘀性脑缺血模型全血黏度、脑匀浆ATP酶及脑组织形态的影响 | |
| 引用本文： | 苗明三,吴巍,陈元朋. 姜黄素对大鼠血瘀性脑缺血模型全血黏度、脑匀浆ATP酶及脑组织形态的影响[J]. 中药新药与临床药理, 2010, 21(2) |
| 作者姓名： | 苗明三 吴巍 陈元朋 |
| 作者单位： | 河南中医学院,郑州,450008 |
| 基金项目： | 国家"重大新药创制"科技重大专项，河南省重大公益性科研计划 |
| 摘 要： | 目的探讨姜黄素对大鼠血瘀性脑缺血模型影响的特点。方法采用注射地塞米松复制血瘀模型,姜黄素混悬液给血瘀模型大鼠连续灌服10d,于第11天给药物后1h,大鼠两侧颈总动脉结扎30min,造脑缺血模型;取血测全血黏度;取大鼠脑,一半脑组织用生理盐水制脑匀浆,测脑匀浆ATP水平;另一半脑组织固定、切片,观察脑组织的病理变化。结果肌肉注射地塞米松可成功复制血瘀模型,结扎双侧颈总动脉可成功复制脑缺血模型。与模型组比较,姜黄素可显著降低血瘀性脑缺血模型全血黏度,显著提高脑匀浆Na+-K+-ATP、Mg2+-ATP、Ca2+-ATP和Ca2+-Mg2+-ATP酶活性,显著改善模型所致脑神经细胞和胶质细胞的萎缩。结论姜黄素可显著改善大鼠血瘀性脑缺血模型全血黏度和脑匀浆ATP酶及脑组织形态。 |
| 关 键 词： | 姜黄素 血瘀 脑缺血 全血黏度 能量代谢 脑组织形态 |
Effect of Curcumine on Whole Blood Viscosity,Cerebral Homogenate ATP Enzyme and Morphology of Brain Tissue in Rat Cerebral Ischemia Model with Blood Stasis |
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| MIAO Mingsan,WU Wei,CHEN Yuanpeng. Effect of Curcumine on Whole Blood Viscosity,Cerebral Homogenate ATP Enzyme and Morphology of Brain Tissue in Rat Cerebral Ischemia Model with Blood Stasis[J]. Traditional Chinese Drug Research & Clinical Pharmacology, 2010, 21(2) | |
| Authors: | MIAO Mingsan WU Wei CHEN Yuanpeng |
| Affiliation: | MIAO Mingsan,WU Wei,CHEN Yuanpeng(Henan College of Traditional Chinese Medicine,Zhengzhou 450008,China) |
| Abstract: | Objective To explore the effect of curcumine on rat cerebral ischemia model of blood stasis.Methods The blood-stasis rat model was established by injection of dexamethasone,then was given gastric infusion curcumine suspension for 10 continuous days.One hour after administration on the 11th day,we made ligation of the bilatory common carotid arteries of rats for 30 min to induce cerebral ischemia rat model.The rat blood sample was used for the detection of whole blood viscosity,and the brain was taken out fo... |
| Keywords: | Curcumine Blood stasis Cerebral ischemia Whole blood viscosity Energy metabolism Brain morphology |
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