Single-nucleotide polymorphisms of the proprotein convertase subtilisin/kexin type 5 (PCSK5) gene |
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| Authors: | H. Cao A. Mok B. Miskie R. A. Hegele |
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| Affiliation: | (1) Blackburn Cardiovascular Genetics Laboratory, John P. Robarts Research Institute, 406-100 Perth Drive, London, ON N6A 5K8, Canada Tel. +1-519-663-3461; Fax +1-519-663-3789 e-mail: robert.hegele@rri.on.ca, CA |
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| Abstract: | ![]()
The proprotein convertase, subtilisin/kexin type 5, or PCSK5, mediates post-translational endoproteolytic processing for several integrin α subunits. We identified two silent single-nucleotide polymorphisms (SNPs) in PCSK5, which were found to vary in frequency across ethnic groups. The identification of these amplification primers and SNPs provides tools to investigate PCSK5 for association with inflammatory or vascular phenotypes. Received: July 23, 2001 / Accepted: August 28, 2001 |
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| Keywords: | Inflammation Cardiovascular disease Genomic DNA Sequencing Complex traits |
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