香术茯苓颗粒止泻、抗炎作用的实验研究

目的：观察香术茯苓颗粒对动物模型的止泻、抗炎作用。方法通过蓖麻油和番泻叶建立两种小鼠腹泻模型，研究香术茯苓颗粒的止泻作用；采用二甲苯诱导小鼠耳肿胀模型，新鲜蛋清诱导大鼠足爪肿胀模型，观察香术茯苓颗粒的抗炎作用。结果香术茯苓颗粒9、18 g/kg 1次给药能减少蓖麻油引起的小鼠腹泻分值，香术茯苓颗粒18 g/kg 1次给药可减少番泻叶引起的小鼠腹泻分值；香术茯苓颗粒18 g/kg 1次给药对二甲苯诱导的小鼠耳肿胀有一定的抑制作用；香术茯苓颗粒16 g/kg 1次给药可抑制新鲜蛋清诱导大鼠足爪肿胀。结论香术茯苓颗粒对动物模型具有止泻作用和抗炎作用。

Antidiarrheal and anti-inflammatory effects of Ageratum rhizoma Atractylodis Tuckahoe granules

Objective To study antidiarrheal and anti-inflammatory effects of Ageratum rhizoma Atractylodis Tucka-hoe granules ( ARTG) . Methods The diarrhea models of castor oil and senna leaf, dimethylbenzene-induced ear swelling and paw edema caused by egg white were used to study ARTG. Results ARTG(9,18 g/kg)single admin-istration could decrease the score of wet dung induced by castor oil, ARTG(18 g/kg) single administration could decrease the score of wet dung induced by senna leaf. ARTG ( 18 g/kg ) single administration could inhibit the swelling degree of ear in mice, ARTG(16 g/kg) single administration could reduce the paws swelling induced by egg white in rats. Conclusion ARTG has antidiarrheal and anti-inflammatory effects on animal models.